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Efficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis.

Authors
 Ji Young Hong  ;  Gyeong Seo Jung  ;  Hyunjung Kim  ;  Young Mi Kim  ;  Hye Jon Lee  ;  Sang-Nae Cho  ;  Se Kyu Kim  ;  Joon Chang  ;  Young Ae Kang 
Citation
 International Journal of Infectious Diseases, Vol.16(12) : 855-859, 2012 
Journal Title
 International Journal of Infectious Diseases 
ISSN
 1201-9712 
Issue Date
2012
Abstract
OBJECTIVE: This study evaluated inducible protein 10 (IP-10) as a diagnostic biomarker for specific tuberculosis (TB) infection and evaluated the ability of IP-10 to distinguish between active TB and latent TB infection (LTBI). METHODS: Forty-six patients with active pulmonary TB, 22 participants with LTBI, and 32 non-TB controls were enrolled separately. We measured IP-10 in serum and in supernatants from whole blood stimulated with TB-specific antigens. RESULTS: TB antigen-dependent IP-10 secretion was significantly increased in the active TB patients and LTBI subjects compared with controls, but did not differ significantly between the active TB patients and LTBI subjects. Serum IP-10 levels were higher in active TB than in LTBI (174.9 vs. 102.7pg/ml, p=0.002). The respective rates of positive responders of TB antigen-dependent IP-10 were 97.8%, 90.9%, and 12.5% in active TB, LTBI, and non-TB controls, respectively. For serum IP-10, 87.5%, 45.5%, and 9.5% of responders were positive in the respective groups. CONCLUSIONS: The IP-10 response to TB antigen may constitute a specific biomarker for TB infection, but does not by itself distinguish between active TB and LTBI. Serum IP-10 may enhance the diagnostic performance when used in combination with another marker.
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DOI
10.1016/j.ijid.2012.07.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Young Mi(김영미)
Kim, Hyun Jung(김현정)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Cho, Sang Nae(조상래)
Hong , Ji Young(홍지영)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90481
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