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Efficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강영애 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김영미 | - |
dc.contributor.author | 김현정 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정경수 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 홍지영 | - |
dc.date.accessioned | 2014-12-19T16:56:34Z | - |
dc.date.available | 2014-12-19T16:56:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90481 | - |
dc.description.abstract | OBJECTIVE: This study evaluated inducible protein 10 (IP-10) as a diagnostic biomarker for specific tuberculosis (TB) infection and evaluated the ability of IP-10 to distinguish between active TB and latent TB infection (LTBI). METHODS: Forty-six patients with active pulmonary TB, 22 participants with LTBI, and 32 non-TB controls were enrolled separately. We measured IP-10 in serum and in supernatants from whole blood stimulated with TB-specific antigens. RESULTS: TB antigen-dependent IP-10 secretion was significantly increased in the active TB patients and LTBI subjects compared with controls, but did not differ significantly between the active TB patients and LTBI subjects. Serum IP-10 levels were higher in active TB than in LTBI (174.9 vs. 102.7pg/ml, p=0.002). The respective rates of positive responders of TB antigen-dependent IP-10 were 97.8%, 90.9%, and 12.5% in active TB, LTBI, and non-TB controls, respectively. For serum IP-10, 87.5%, 45.5%, and 9.5% of responders were positive in the respective groups. CONCLUSIONS: The IP-10 response to TB antigen may constitute a specific biomarker for TB infection, but does not by itself distinguish between active TB and LTBI. Serum IP-10 may enhance the diagnostic performance when used in combination with another marker. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chemokine CXCL10/blood* | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Latent Tuberculosis/blood | - |
dc.subject.MESH | Latent Tuberculosis/diagnosis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Tuberculin Test | - |
dc.subject.MESH | Tuberculosis, Pulmonary/blood | - |
dc.subject.MESH | Tuberculosis, Pulmonary/diagnosis* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Efficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Ji Young Hong | - |
dc.contributor.googleauthor | Gyeong Seo Jung | - |
dc.contributor.googleauthor | Hyunjung Kim | - |
dc.contributor.googleauthor | Young Mi Kim | - |
dc.contributor.googleauthor | Hye Jon Lee | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 22959355 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00705 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03570 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A04441 | - |
dc.contributor.localId | A01131 | - |
dc.relation.journalcode | J01125 | - |
dc.identifier.eissn | 1878-3511 | - |
dc.identifier.pmid | 22959355 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Biomarkers/blood* | - |
dc.subject.keyword | Case-Control Studies | - |
dc.subject.keyword | Chemokine CXCL10/blood* | - |
dc.subject.keyword | Diagnosis, Differential | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Latent Tuberculosis/blood | - |
dc.subject.keyword | Latent Tuberculosis/diagnosis* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Mycobacterium tuberculosis/immunology | - |
dc.subject.keyword | Predictive Value of Tests | - |
dc.subject.keyword | Republic of Korea | - |
dc.subject.keyword | Tuberculin Test | - |
dc.subject.keyword | Tuberculosis, Pulmonary/blood | - |
dc.subject.keyword | Tuberculosis, Pulmonary/diagnosis* | - |
dc.subject.keyword | Young Adult | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Young Mi | - |
dc.contributor.alternativeName | Kim, Hyun Jung | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Kyung Soo | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Hong, Ji Young | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Young Mi | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Hong , Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jung | - |
dc.citation.volume | 16 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 855 | - |
dc.citation.endPage | 859 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.16(12) : 855-859, 2012 | - |
dc.identifier.rimsid | 32793 | - |
dc.type.rims | ART | - |
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