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Efficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis.

DC Field Value Language
dc.contributor.author강영애-
dc.contributor.author김세규-
dc.contributor.author김영미-
dc.contributor.author김현정-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author조상래-
dc.contributor.author홍지영-
dc.date.accessioned2014-12-19T16:56:34Z-
dc.date.available2014-12-19T16:56:34Z-
dc.date.issued2012-
dc.identifier.issn1201-9712-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90481-
dc.description.abstractOBJECTIVE: This study evaluated inducible protein 10 (IP-10) as a diagnostic biomarker for specific tuberculosis (TB) infection and evaluated the ability of IP-10 to distinguish between active TB and latent TB infection (LTBI). METHODS: Forty-six patients with active pulmonary TB, 22 participants with LTBI, and 32 non-TB controls were enrolled separately. We measured IP-10 in serum and in supernatants from whole blood stimulated with TB-specific antigens. RESULTS: TB antigen-dependent IP-10 secretion was significantly increased in the active TB patients and LTBI subjects compared with controls, but did not differ significantly between the active TB patients and LTBI subjects. Serum IP-10 levels were higher in active TB than in LTBI (174.9 vs. 102.7pg/ml, p=0.002). The respective rates of positive responders of TB antigen-dependent IP-10 were 97.8%, 90.9%, and 12.5% in active TB, LTBI, and non-TB controls, respectively. For serum IP-10, 87.5%, 45.5%, and 9.5% of responders were positive in the respective groups. CONCLUSIONS: The IP-10 response to TB antigen may constitute a specific biomarker for TB infection, but does not by itself distinguish between active TB and LTBI. Serum IP-10 may enhance the diagnostic performance when used in combination with another marker.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChemokine CXCL10/blood*-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLatent Tuberculosis/blood-
dc.subject.MESHLatent Tuberculosis/diagnosis*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycobacterium tuberculosis/immunology-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTuberculin Test-
dc.subject.MESHTuberculosis, Pulmonary/blood-
dc.subject.MESHTuberculosis, Pulmonary/diagnosis*-
dc.subject.MESHYoung Adult-
dc.titleEfficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorJi Young Hong-
dc.contributor.googleauthorGyeong Seo Jung-
dc.contributor.googleauthorHyunjung Kim-
dc.contributor.googleauthorYoung Mi Kim-
dc.contributor.googleauthorHye Jon Lee-
dc.contributor.googleauthorSang-Nae Cho-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorYoung Ae Kang-
dc.identifier.doi22959355-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00602-
dc.contributor.localIdA00705-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03824-
dc.contributor.localIdA04441-
dc.contributor.localIdA01131-
dc.relation.journalcodeJ01125-
dc.identifier.eissn1878-3511-
dc.identifier.pmid22959355-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordBiomarkers/blood*-
dc.subject.keywordCase-Control Studies-
dc.subject.keywordChemokine CXCL10/blood*-
dc.subject.keywordDiagnosis, Differential-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordLatent Tuberculosis/blood-
dc.subject.keywordLatent Tuberculosis/diagnosis*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMycobacterium tuberculosis/immunology-
dc.subject.keywordPredictive Value of Tests-
dc.subject.keywordRepublic of Korea-
dc.subject.keywordTuberculin Test-
dc.subject.keywordTuberculosis, Pulmonary/blood-
dc.subject.keywordTuberculosis, Pulmonary/diagnosis*-
dc.subject.keywordYoung Adult-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Young Mi-
dc.contributor.alternativeNameKim, Hyun Jung-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.alternativeNameHong, Ji Young-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Young Mi-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorCho, Sang Nae-
dc.contributor.affiliatedAuthorHong , Ji Young-
dc.contributor.affiliatedAuthorKim, Hyun Jung-
dc.citation.volume16-
dc.citation.number12-
dc.citation.startPage855-
dc.citation.endPage859-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.16(12) : 855-859, 2012-
dc.identifier.rimsid32793-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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