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Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology.

 Hur, Jin  ;  Kim, Young Jin  ;  Shim, Hyo Sup  ;  Lee, Hye-Jeong  ;  Nam, Ji Eun 
 International Journal of Cardiovascular Imaging, Vol.28(2) : 353-363, 2012 
Journal Title
 International Journal of Cardiovascular Imaging 
Issue Date
Animals ; Aorta, Abdominal/chemistry ; Aorta, Abdominal/diagnostic imaging* ; Aorta, Abdominal/pathology* ; Aortic Diseases/diagnosis* ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Aortography/methods* ; Atherosclerosis/diagnosis* ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Contrast Media* ; Disease Models, Animal ; Fibrosis ; Lipids/analysis ; Macrophages/diagnostic imaging ; Macrophages/pathology ; Male ; Plaque, Atherosclerotic/chemistry ; Plaque, Atherosclerotic/diagnosis* ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/pathology ; Predictive Value of Tests ; Rabbits ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed*
Computed tomography angiography (CTA) ; Atherosclerotic plaque ; Composition
The aim of this study was to compare delayed-phase computed tomography angiography (CTA) attenuation values with histopathology, in ability to differentiate between fibrous and lipid-rich plaques in an experimental rabbit model. Twelve atherosclerotic rabbits underwent CTA of the abdominal aorta. The scan protocol included early-phase scans (EP), delayed scans at 90 s after contrast injection (DP(90s)), delayed scans at 10 min after contrast injection (DP(10min)), and delayed scan with saline infusion (DP(Saline)). Plaque composition was analyzed by histopathology (% of lipid-rich, fibrous and macrophage areas) and CT attenuation values in Hounsfield units. Using histopathology as the reference standard (n = 119), the overall sensitivity, specificity and accuracy of 64-slice CTA for the detection of plaques was 59, 100 and 79% for the EP scans; 88, 100 and 94% for the DP(90s) scans; 81, 100 and 90% for the DP(10min) scans; and 53, 100 and 76% for the DP(Saline) scans. CT density measurements showed a substantial overlap between fibrous and lipid-rich plaques, and poor correlations with the percentage of macrophage areas in both fibrous and lipid-rich plaques (r = 0.408, and r = 0.333). In delayed-phase 64-slice CTA, DP(90s) images have the best diagnostic performance for the detection of aortic plaques.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Nam, Ji Eun(남지은)
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
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