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Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology.

DC FieldValueLanguage
dc.contributor.author김영진-
dc.contributor.author남지은-
dc.contributor.author심효섭-
dc.contributor.author이혜정-
dc.contributor.author최규옥-
dc.contributor.author최병욱-
dc.contributor.author허진-
dc.date.accessioned2014-12-19T16:55:34Z-
dc.date.available2014-12-19T16:55:34Z-
dc.date.issued2012-
dc.identifier.issn1569-5794-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90451-
dc.description.abstractThe aim of this study was to compare delayed-phase computed tomography angiography (CTA) attenuation values with histopathology, in ability to differentiate between fibrous and lipid-rich plaques in an experimental rabbit model. Twelve atherosclerotic rabbits underwent CTA of the abdominal aorta. The scan protocol included early-phase scans (EP), delayed scans at 90 s after contrast injection (DP(90s)), delayed scans at 10 min after contrast injection (DP(10min)), and delayed scan with saline infusion (DP(Saline)). Plaque composition was analyzed by histopathology (% of lipid-rich, fibrous and macrophage areas) and CT attenuation values in Hounsfield units. Using histopathology as the reference standard (n = 119), the overall sensitivity, specificity and accuracy of 64-slice CTA for the detection of plaques was 59, 100 and 79% for the EP scans; 88, 100 and 94% for the DP(90s) scans; 81, 100 and 90% for the DP(10min) scans; and 53, 100 and 76% for the DP(Saline) scans. CT density measurements showed a substantial overlap between fibrous and lipid-rich plaques, and poor correlations with the percentage of macrophage areas in both fibrous and lipid-rich plaques (r = 0.408, and r = 0.333). In delayed-phase 64-slice CTA, DP(90s) images have the best diagnostic performance for the detection of aortic plaques.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAorta, Abdominal/chemistry-
dc.subject.MESHAorta, Abdominal/diagnostic imaging*-
dc.subject.MESHAorta, Abdominal/pathology*-
dc.subject.MESHAortic Diseases/diagnosis*-
dc.subject.MESHAortic Diseases/diagnostic imaging-
dc.subject.MESHAortic Diseases/metabolism-
dc.subject.MESHAortic Diseases/pathology-
dc.subject.MESHAortography/methods*-
dc.subject.MESHAtherosclerosis/diagnosis*-
dc.subject.MESHAtherosclerosis/diagnostic imaging-
dc.subject.MESHAtherosclerosis/metabolism-
dc.subject.MESHAtherosclerosis/pathology-
dc.subject.MESHContrast Media*-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFibrosis-
dc.subject.MESHLipids/analysis-
dc.subject.MESHMacrophages/diagnostic imaging-
dc.subject.MESHMacrophages/pathology-
dc.subject.MESHMale-
dc.subject.MESHPlaque, Atherosclerotic/chemistry-
dc.subject.MESHPlaque, Atherosclerotic/diagnosis*-
dc.subject.MESHPlaque, Atherosclerotic/diagnostic imaging-
dc.subject.MESHPlaque, Atherosclerotic/pathology-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRabbits-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTomography, X-Ray Computed*-
dc.titleAssessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHur, Jin-
dc.contributor.googleauthorKim, Young Jin-
dc.contributor.googleauthorShim, Hyo Sup-
dc.contributor.googleauthorLee, Hye-Jeong-
dc.contributor.googleauthorNam, Ji Eun-
dc.identifier.doi21279690-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03320-
dc.contributor.localIdA00727-
dc.contributor.localIdA01269-
dc.contributor.localIdA02219-
dc.contributor.localIdA04042-
dc.contributor.localIdA04059-
dc.contributor.localIdA04370-
dc.relation.journalcodeJ01094-
dc.identifier.eissn1875-8312-
dc.identifier.pmid21279690-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10554-011-9801-x-
dc.subject.keywordComputed tomography angiography (CTA)-
dc.subject.keywordAtherosclerotic plaque-
dc.subject.keywordComposition-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.alternativeNameNam, Ji Eun-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameLee, Hye Jeong-
dc.contributor.alternativeNameChoe, Kyu Ok-
dc.contributor.alternativeNameChoi, Byoung Wook-
dc.contributor.alternativeNameHur, Jin-
dc.contributor.affiliatedAuthorLee, Hye Jeong-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.contributor.affiliatedAuthorNam, Ji Eun-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorChoe, Kyu Ok-
dc.contributor.affiliatedAuthorChoi, Byoung Wook-
dc.contributor.affiliatedAuthorHur, Jin-
dc.citation.volume28-
dc.citation.number2-
dc.citation.startPage353-
dc.citation.endPage363-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.28(2) : 353-363, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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