3 206

Cited 12 times in

Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing.

Authors
 Seung Hee Baek  ;  Hae Weon Cho  ;  Young-Chang Kwon  ;  Ji Hyun Lee  ;  Moon Jong Kim  ;  Hyangkyu Lee  ;  Kwang-Min Choe 
Citation
 FEBS Letters, Vol.586(6) : 772-777, 2012 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
2012
MeSH
Actins/metabolism* ; Animals ; Drosophila Proteins/metabolism* ; Drosophila melanogaster/physiology* ; Epidermis/pathology ; Epidermis/physiology ; Larva/anatomy & histology ; Larva/physiology* ; Myosins/metabolism* ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Wound Healing/physiology ; p21-Activated Kinases/genetics ; p21-Activated Kinases/metabolism* ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism*
Keywords
Wound repair ; Cell migration ; Chemotaxis ; Cell polarization ; Actin cable
Abstract
Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of the Drosophila larval epidermis. Pak3-deficient larvae failed to close a wound hole and this defect was not rescued by Pak1 expression, indicating differential functions of the two proteins. Pak3 localized to the wound margin, which selectively required Rac1. Pak3-deficient larvae showed severe defects in actin-myosin organization at the wound margin and in submarginal cells, which was reminiscent of the phenotypes of Rac1-deficient larvae. These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing.
Full Text
http://www.sciencedirect.com/science/article/pii/S001457931200110X
DOI
22449966
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Lee, Hyang Kyu(이향규) ORCID logo https://orcid.org/0000-0002-0821-6020
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90291
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse