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Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing.

Authors
 Seung Hee Baek  ;  Hae Weon Cho  ;  Young-Chang Kwon  ;  Ji Hyun Lee  ;  Moon Jong Kim  ;  Hyangkyu Lee  ;  Kwang-Min Choe 
Citation
 FEBS Letters, Vol.586(6) : 772-777, 2012 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
2012
Abstract
Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of the Drosophila larval epidermis. Pak3-deficient larvae failed to close a wound hole and this defect was not rescued by Pak1 expression, indicating differential functions of the two proteins. Pak3 localized to the wound margin, which selectively required Rac1. Pak3-deficient larvae showed severe defects in actin-myosin organization at the wound margin and in submarginal cells, which was reminiscent of the phenotypes of Rac1-deficient larvae. These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing.
Full Text
http://www.sciencedirect.com/science/article/pii/S001457931200110X
DOI
10.1016/j.febslet.2012.01.061
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
이향규(Lee, Hyang Kyu) ORCID logo https://orcid.org/0000-0002-0821-6020
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90291
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