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Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing.
DC Field | Value | Language |
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dc.contributor.author | 이향규 | - |
dc.date.accessioned | 2014-12-19T16:50:21Z | - |
dc.date.available | 2014-12-19T16:50:21Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90291 | - |
dc.description.abstract | Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of the Drosophila larval epidermis. Pak3-deficient larvae failed to close a wound hole and this defect was not rescued by Pak1 expression, indicating differential functions of the two proteins. Pak3 localized to the wound margin, which selectively required Rac1. Pak3-deficient larvae showed severe defects in actin-myosin organization at the wound margin and in submarginal cells, which was reminiscent of the phenotypes of Rac1-deficient larvae. These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Actins/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Drosophila Proteins/metabolism* | - |
dc.subject.MESH | Drosophila melanogaster/physiology* | - |
dc.subject.MESH | Epidermis/pathology | - |
dc.subject.MESH | Epidermis/physiology | - |
dc.subject.MESH | Larva/anatomy & histology | - |
dc.subject.MESH | Larva/physiology* | - |
dc.subject.MESH | Myosins/metabolism* | - |
dc.subject.MESH | Recombinant Fusion Proteins/genetics | - |
dc.subject.MESH | Recombinant Fusion Proteins/metabolism | - |
dc.subject.MESH | Wound Healing/physiology | - |
dc.subject.MESH | p21-Activated Kinases/genetics | - |
dc.subject.MESH | p21-Activated Kinases/metabolism* | - |
dc.subject.MESH | rac1 GTP-Binding Protein/genetics | - |
dc.subject.MESH | rac1 GTP-Binding Protein/metabolism* | - |
dc.title | Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing. | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing Environment SyStems (임상간호과학과) | - |
dc.contributor.googleauthor | Seung Hee Baek | - |
dc.contributor.googleauthor | Hae Weon Cho | - |
dc.contributor.googleauthor | Young-Chang Kwon | - |
dc.contributor.googleauthor | Ji Hyun Lee | - |
dc.contributor.googleauthor | Moon Jong Kim | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.contributor.googleauthor | Kwang-Min Choe | - |
dc.identifier.doi | 22449966 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03282 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 22449966 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S001457931200110X | - |
dc.subject.keyword | Wound repair | - |
dc.subject.keyword | Cell migration | - |
dc.subject.keyword | Chemotaxis | - |
dc.subject.keyword | Cell polarization | - |
dc.subject.keyword | Actin cable | - |
dc.contributor.alternativeName | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Hyang Kyu | - |
dc.citation.volume | 586 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 772 | - |
dc.citation.endPage | 777 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.586(6) : 772-777, 2012 | - |
dc.identifier.rimsid | 34120 | - |
dc.type.rims | ART | - |
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