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Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer.

Authors
 Joon Seok Lim  ;  Daehong Kim  ;  Song-Ee Baek  ;  Sungmin Myoung  ;  Junjeong Choi  ;  Sang Joon Shin  ;  Myeong-Jin Kim  ;  Nam Kyu Kim  ;  Jinsuk Suh  ;  Ki Whang Kim  ;  Ki Chang Keum 
Citation
 European Radiology, Vol.22(8) : 1693-1700, 2012 
Journal Title
 European Radiology 
ISSN
 0938-7994 
Issue Date
2012
Abstract
OBJECTIVES: To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. METHODS: Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The K (trans) (volume transfer constant) and V (e) (extracellular extravascular space fraction) were calculated. RESULTS: Before CRT, the mean tumour K (trans) in the downstaged group was significantly higher than that in the non-downstaged group (P = 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P = 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of K (trans) values both between downstaged and non-downstaged groups (P = 0.0215) and between TRG responders and TRG non-responders (P = 0.0001). Regarding V (e), no significant differences were observed both between downstaged and non-downstaged groups (P = 0.689) or between TRG responders and TRG non-responders (P = 0.887). CONCLUSION: Perfusion MRI of rectal cancer can be useful for assessing tumoural K (trans) changes by CRT. Tumours with high pre-CRT K (trans) values tended to respond favourably to CRT, particularly in terms of downstaging criteria. KEY POINTS: • Perfusion MRI can now assess therapeutic response of tumours to therapy. • Tumours with high initial K ( trans ) values responded favourably to chemoradiotherapy. • Perfusion MRI of rectal cancer may help with decisions about management.
Full Text
http://link.springer.com/article/10.1007%2Fs00330-012-2416-3
DOI
10.1007/s00330-012-2416-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김기황(Kim, Ki Whang)
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
백송이(Baek, Song Ee) ORCID logo https://orcid.org/0000-0001-8146-2570
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
임준석(Lim, Joon Seok) ORCID logo https://orcid.org/0000-0002-0334-5042
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90249
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