Cited 88 times in
Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 김기황 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 백송이 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 임준석 | - |
dc.date.accessioned | 2014-12-19T16:49:02Z | - |
dc.date.available | 2014-12-19T16:49:02Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90249 | - |
dc.description.abstract | OBJECTIVES: To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. METHODS: Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The K (trans) (volume transfer constant) and V (e) (extracellular extravascular space fraction) were calculated. RESULTS: Before CRT, the mean tumour K (trans) in the downstaged group was significantly higher than that in the non-downstaged group (P = 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P = 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of K (trans) values both between downstaged and non-downstaged groups (P = 0.0215) and between TRG responders and TRG non-responders (P = 0.0001). Regarding V (e), no significant differences were observed both between downstaged and non-downstaged groups (P = 0.689) or between TRG responders and TRG non-responders (P = 0.887). CONCLUSION: Perfusion MRI of rectal cancer can be useful for assessing tumoural K (trans) changes by CRT. Tumours with high pre-CRT K (trans) values tended to respond favourably to CRT, particularly in terms of downstaging criteria. KEY POINTS: • Perfusion MRI can now assess therapeutic response of tumours to therapy. • Tumours with high initial K ( trans ) values responded favourably to chemoradiotherapy. • Perfusion MRI of rectal cancer may help with decisions about management. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Carcinoma/pathology* | - |
dc.subject.MESH | Carcinoma/therapy* | - |
dc.subject.MESH | Chemoradiotherapy/methods* | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Contrast Media/pharmacology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Angiography/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Perfusion | - |
dc.subject.MESH | Permeability | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Rectal Neoplasms/pathology* | - |
dc.subject.MESH | Rectal Neoplasms/therapy* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Daehong Kim | - |
dc.contributor.googleauthor | Song-Ee Baek | - |
dc.contributor.googleauthor | Sungmin Myoung | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Jinsuk Suh | - |
dc.contributor.googleauthor | Ki Whang Kim | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 10.1007/s00330-012-2416-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00345 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A01822 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A03408 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 22427184 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00330-012-2416-3 | - |
dc.subject.keyword | Magnetic resonance imaging (MRI) | - |
dc.subject.keyword | Perfusion imaging | - |
dc.subject.keyword | Dynamic contrast-enhanced MRI | - |
dc.subject.keyword | Rectal cancer | - |
dc.subject.keyword | Chemoradiotherapy (CRT) | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Ki Whang | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Baek, Song Ee | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Lim, Joon Seok | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Ki Whang | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Baek, Song Ee | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Lim, Joon Seok | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1693 | - |
dc.citation.endPage | 1700 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.22(8) : 1693-1700, 2012 | - |
dc.identifier.rimsid | 34093 | - |
dc.type.rims | ART | - |
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