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Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer.

Authors
 S.G. Hwang  ;  K.M. Kim  ;  J.H. Cheong  ;  H.I. Kim  ;  J.Y. An  ;  W.J. Hyung  ;  S.H. Noh 
Citation
 EJSO, Vol.38(7) : 562-567, 2012 
Journal Title
 EJSO 
ISSN
 0748-7983 
Issue Date
2012
MeSH
Adenocarcinoma/complications ; Adenocarcinoma/mortality ; Adenocarcinoma/secondary* ; Adenocarcinoma/surgery ; Analysis of Variance ; Female ; Gastrectomy* ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Neoplastic Cells, Circulating* ; Odds Ratio ; Platelet Activation ; Platelet Count ; Predictive Value of Tests ; Preoperative Period ; Prognosis ; Prospective Studies ; Risk Factors ; Stomach Neoplasms/complications ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery ; Survival Analysis ; Thrombocytosis/complications*
Keywords
Stomach neoplasm ; Blood platelets ; Thrombocytosis ; Prognosis ; Recurrence ; Neoplasm metastasis
Abstract
BACKGROUND: Thrombocytosis has been associated with malignancies and poor prognostic implications in cancer patients. In the present study the prognostic significance of pretreatment platelet (PLT) level was assessed with regard to recurrence and survival in patients with primary gastric adenocarcinoma. METHODS: The authors reviewed the prospective data of 1593 gastric cancer patients who received curative gastrectomy with extended lymphadenectomy. The correlations of PLT level with recurrence and overall survival were evaluated by both univariate and multivariate analyses. RESULTS: Thrombocytosis (≥ 40 × 10(4)/ μL), present in 6.4% of the patients prior to curative surgery, was more frequently associated with advanced T and N classification, larger tumor size, anemia, and leukocytosis (p < 0.05). In patients with pretreatment thrombocytosis compared to those without it, five-year survival rate was worse (56.9% vs. 65.5%; p = 0.043), and recurrence rate was higher mainly due to the frequent hematogenous spread (51.0% vs. 34.5%; p < 0.001). Furthermore, risk of blood-borne metastasis was almost three-fold higher in patients with pretreatment thrombocytosis (Odds ratio 2.83 [95% CI 1.67-4.77], p < 0.001). CONCLUSIONS: Pretreatment thrombocytosis correlated significantly with poor prognosis and can be used as an independent predictor of recurrence by blood-borne metastasis in gastric cancer.
Full Text
http://www.sciencedirect.com/science/article/pii/S0748798312002946
DOI
22592098
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90241
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