Cited 71 times in
Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 안지영 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 김형일 | - |
dc.contributor.author | 노성훈 | - |
dc.date.accessioned | 2014-12-19T16:48:46Z | - |
dc.date.available | 2014-12-19T16:48:46Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0748-7983 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90241 | - |
dc.description.abstract | BACKGROUND: Thrombocytosis has been associated with malignancies and poor prognostic implications in cancer patients. In the present study the prognostic significance of pretreatment platelet (PLT) level was assessed with regard to recurrence and survival in patients with primary gastric adenocarcinoma. METHODS: The authors reviewed the prospective data of 1593 gastric cancer patients who received curative gastrectomy with extended lymphadenectomy. The correlations of PLT level with recurrence and overall survival were evaluated by both univariate and multivariate analyses. RESULTS: Thrombocytosis (≥ 40 × 10(4)/ μL), present in 6.4% of the patients prior to curative surgery, was more frequently associated with advanced T and N classification, larger tumor size, anemia, and leukocytosis (p < 0.05). In patients with pretreatment thrombocytosis compared to those without it, five-year survival rate was worse (56.9% vs. 65.5%; p = 0.043), and recurrence rate was higher mainly due to the frequent hematogenous spread (51.0% vs. 34.5%; p < 0.001). Furthermore, risk of blood-borne metastasis was almost three-fold higher in patients with pretreatment thrombocytosis (Odds ratio 2.83 [95% CI 1.67-4.77], p < 0.001). CONCLUSIONS: Pretreatment thrombocytosis correlated significantly with poor prognosis and can be used as an independent predictor of recurrence by blood-borne metastasis in gastric cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EJSO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/complications | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/secondary* | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrectomy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neoplastic Cells, Circulating* | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Platelet Activation | - |
dc.subject.MESH | Platelet Count | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Preoperative Period | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms/complications | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.subject.MESH | Stomach Neoplasms/surgery | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Thrombocytosis/complications* | - |
dc.title | Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | S.G. Hwang | - |
dc.contributor.googleauthor | K.M. Kim | - |
dc.contributor.googleauthor | J.H. Cheong | - |
dc.contributor.googleauthor | H.I. Kim | - |
dc.contributor.googleauthor | J.Y. An | - |
dc.contributor.googleauthor | W.J. Hyung | - |
dc.contributor.googleauthor | S.H. Noh | - |
dc.identifier.doi | 10.1016/j.ejso.2012.04.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A04382 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A01281 | - |
dc.relation.journalcode | J00847 | - |
dc.identifier.eissn | 1532-2157 | - |
dc.identifier.pmid | 22592098 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0748798312002946 | - |
dc.subject.keyword | Stomach neoplasm | - |
dc.subject.keyword | Blood platelets | - |
dc.subject.keyword | Thrombocytosis | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Neoplasm metastasis | - |
dc.contributor.alternativeName | An, Ji Yeong | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.alternativeName | Kim, Hyoung Il | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Il | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.citation.volume | 38 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 562 | - |
dc.citation.endPage | 567 | - |
dc.identifier.bibliographicCitation | EJSO, Vol.38(7) : 562-567, 2012 | - |
dc.identifier.rimsid | 34089 | - |
dc.type.rims | ART | - |
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