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Effect of Ligand Structure on MnO Nanoparticles for Enhanced T1 Magnetic Resonance Imaging of Inflammatory Macrophages

Authors
 Joseph Park  ;  Doyeon Bang  ;  Eunjung Kim  ;  Jaemoon Yang  ;  Eun-Kyung Lim  ;  Jihye Choi  ;  Byunghoon Kang  ;  Jin-Suck Suh  ;  Hyo Seon Park  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Vol.2012 : 5960-5965, 2012 
Journal Title
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
ISSN
 1434-1948 
Issue Date
2012
Keywords
Nanomaterials ; Nanoparticles ; Imaging agents ; Magnetic resonance imaging ; Ligand effects ; Manganese
Abstract
Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ejic.201201026/abstract
DOI
10.1002/ejic.201201026
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Lim, Eun Kyung(임은경)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90201
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