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Association between serum total bilirubin level and leukoaraiosis in Korean adults.

Authors
 Byoung-Jin Parka  ;  Jae-Yong Shima  ;  Hye-Ree Leea  ;  Hee-Taik Kanga  ;  Jung-Hyun Leeb  ;  Yong-Jae Leea 
Citation
 CLINICAL BIOCHEMISTRY, Vol.45(4-5) : 289-292, 2012 
Journal Title
 CLINICAL BIOCHEMISTRY 
ISSN
 0009-9120 
Issue Date
2012
MeSH
Bilirubin/blood* ; Cerebral Angiography ; Cross-Sectional Studies ; Female ; Hospitals, Urban ; Humans ; Leukoaraiosis/blood* ; Leukoaraiosis/epidemiology ; Leukoaraiosis/ethnology ; Magnetic Resonance Angiography ; Male ; Medical Records ; Middle Aged ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Sex Characteristics
Keywords
Bilirubin ; Leukoaraiosis ; Cerebral microangiopathy
Abstract
OBJECTIVES: Leukoaraiosis is associated with cerebrovascular microangiopathy. Increasing evidence suggests that bilirubin is a potent cytoprotectant in the development of cardiovascular diseases. This study aimed to determine whether total bilirubin is related to leukoaraiosis. METHODS: We examined the relationship of total bilirubin with leukoaraiosis in 1005 Korean adults. The odds ratios for leukoaraiosis were calculated using multivariate logistic regression across serum total bilirubin tertiles. RESULTS: In comparison with the subjects in the reference group (total bilirubin: 15-26 μmol/L), the odds ratio (95% CI) for leukoaraiosis in the 3rd tertile (total bilirubin ≤10 μmol/L) was 5.50 (1.24-24.40) in women after adjusting for confounding variables. However, this inverse association between serum total bilirubin and the prevalence of leukoaraiosis was not found in men after adjusting for the same co-variables. CONCLUSION: Total bilirubin level was inversely associated with leukoaraiosis regardless of classical cardiovascular risk factors in Korean women.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009912012000021
DOI
22245549
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Taik(강희택)
Park, Byoung Jin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90005
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