2 416

Cited 0 times in

Response evaluation in patients with colorectal liver metastases: RECIST version 1.1 versus modified CT criteria

Authors
 Woo-Suk Chung  ;  Mi-Suk Park  ;  Sang Joon Shin  ;  Song-Ee Baek  ;  Yeo-Eun Kim  ;  Jin Young Choi  ;  Myeong-Jin Kim 
Citation
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.199(4) : 809-815, 2012 
Journal Title
AMERICAN JOURNAL OF ROENTGENOLOGY
ISSN
 0361-803X 
Issue Date
2012
MeSH
Adult ; Aged ; Angiogenesis Inhibitors/therapeutic use* ; Antibodies, Monoclonal, Humanized/therapeutic use* ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Bevacizumab ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/drug therapy* ; Colorectal Neoplasms/pathology* ; Contrast Media ; Humans ; Image Processing, Computer-Assisted ; Iohexol/analogs & derivatives ; Liver Neoplasms/diagnostic imaging* ; Liver Neoplasms/secondary* ; Male ; Middle Aged ; Multidetector Computed Tomography* ; Prognosis
Keywords
colorectal cancer ; liver metastasis ; modified CT criteria ; RECIST 1.1 ; Response Evaluation Criteria in Solid Tumors (RECIST) ; treatment response ; tumor density ; tumor size
Abstract
OBJECTIVE: Our retrospective study compared Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with modified CT criteria to determine their respective utilities as a prognostic indicator. Using both sets of criteria, we compared treatment responses of patients with colorectal liver metastases treated with bevacizumab-containing chemotherapy with those of patients treated with chemotherapy alone.

MATERIALS AND METHODS: Fifty-nine patients who received bevacizumab-containing chemotherapy (n=30, group 1) or chemotherapy alone (n=29, group 2) for the treatment of colorectal carcinoma underwent contrast-enhanced CT before treatment and 2 months after treatment. Two radiologists determined changes in tumor size and density between the pretreatment and 2-month follow-up CT images. RECIST 1.1 assesses responses on the basis of changes in tumor size, and the modified CT criteria assesses responses on the basis of changes in tumor density and size. Responses were correlated with time to tumor progression by log rank test.

RESULTS: According to RECIST 1.1, nine of 30 patients (30%) in group 1 and 12 of 29 patients (41%) in group 2 were good responders. According to the modified CT criteria, 23 of 30 patients in group 1 (77%) and 23 of 29 patients in group 2 (79%) were good responders. As assessed by the modified CT criteria, good responders in both groups had significantly longer time to tumor progression than poor responders (p<0.05). As assessed by RECIST 1.1, good responders in group 1 had significantly longer time to tumor progression than poor responders (p=0.0154), but there was no difference in group 2.

CONCLUSION: Evaluating treatment response with tumor size and density changes on CT was a better predictor of time to tumor progression than changes in tumor size alone in both groups.
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.11.7910
DOI
22997372
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Yeo Eun(김여은)
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Baek, Song Ee(백송이) ORCID logo https://orcid.org/0000-0001-8146-2570
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Chung, Woo Suk(정우석)
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89450
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links