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Neural network functional connectivity during and after an episode of delirium

Authors
 Soo-Hee Choi  ;  Hyeongrae Lee  ;  Tae-Sub Chung  ;  Kyung-Min Park  ;  Young-Chul Jung  ;  Sun I. Kim  ;  Jae-Jin Kim 
Citation
 AMERICAN JOURNAL OF PSYCHIATRY, Vol.169(5) : 498-507, 2012 
Journal Title
 AMERICAN JOURNAL OF PSYCHIATRY 
ISSN
 0002-953X 
Issue Date
2012
MeSH
Aged ; Case-Control Studies ; Delirium/etiology ; Delirium/physiopathology* ; Female ; Functional Neuroimaging ; Gyrus Cinguli/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Nerve Net/physiopathology* ; Prefrontal Cortex/physiopathology ; Severity of Illness Index
Keywords
Aged ; Case-Control Studies ; Delirium/etiology ; Delirium/physiopathology* ; Female ; Functional Neuroimaging ; Gyrus Cinguli/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Nerve Net/physiopathology* ; Prefrontal Cortex/physiopathology ; Severity of Illness Index
Abstract
OBJECTIVE: Delirium is a common and potentially life-threatening clinical syndrome. The authors investigated resting-state functional connectivity in patients with delirium to elucidate possible neural mechanisms underlying this disorder. METHOD: Twenty-two patients underwent initial functional MRI at rest during an episode of delirium. Of these patients, 14 completed follow-up scans after the episode resolved. Twenty-two comparison subjects without delirium also underwent scanning. The authors assessed cortical functional connectivity using the seed region of the posterior cingulate cortex and functional connectivity strengths between a priori subcortical regions related to acetylcholine and dopamine on data from 20 initial and 13 follow-up scans. RESULTS: Dorsolateral prefrontal cortex activity and posterior cingulate cortex activity were inversely correlated in comparison subjects but strongly correlated in patients during an episode of delirium as indicated by increased functional connectivity between the two regions. Although precuneus activity was positively correlated with posterior cingulate cortex activity in comparison subjects, the correlation was further increased in patients during an episode of delirium, and the increment was associated with less severity and shorter duration of delirium. Functional connectivity strengths of the intralaminar thalamic and caudate nuclei with other subcortical regions were reduced during an episode of delirium but recovered after resolution of the episode. CONCLUSIONS: These findings suggest that the disruption in reciprocity of the dorsolateral prefrontal cortex with the posterior cingulate cortex and reversible reduction of functional connectivity of subcortical regions may underlie the pathophysiology of delirium. In addition, enhanced integration in the posteromedial cortices may account for facilitating the rapid improvement of delirium.
Full Text
http://ajp.psychiatryonline.org/article.aspx?articleid=1109027
DOI
22549209
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Kyoung Min(박경민)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
Chung, Tae Sub(정태섭)
Choi, Soo Hee(최수희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89440
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