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Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors: An initial experience

 Seung Hyun Lee  ;  Jin Hur  ;  Young Jin Kim  ;  Hye-Jeong Lee  ;  Yoo Jin Hong  ;  Byoung Wook Choi 
 European Journal of Radiology, Vol.82(11) : 2043-2049, 2013 
Journal Title
 European Journal of Radiology 
Issue Date
Diagnosis, Differential ; Female ; Humans ; Male ; Mediastinal Neoplasms/diagnostic imaging* ; Middle Aged ; Pilot Projects ; Radiography, Dual-Energy Scanned Projection/methods* ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods*
Benign neoplasm ; Differentiation ; Dual-energy computed tomography ; Malignant neoplasm ; Mediastinal neopla는
OBJECTIVES: To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. MATERIALS AND METHODS: We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. RESULTS: 10 patients (40%) had benign pathology, while 15 (60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p=0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p=0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p=0.067 and 67.4 HU vs. 78.4 HU, p=0.086, respectively). CONCLUSIONS: Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
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