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Fasting Glucose Level and the Risk of Incident Atherosclerotic Cardiovascular Diseases

Authors
 Chanshin Park  ;  Eliseo Guallar  ;  John A. Linton  ;  Duk-Chul Lee  ;  Yangsoo Jang  ;  Dong Koog Son  ;  Eun-Jeong Han  ;  Soo Jin Baek  ;  Young Duk Yun  ;  Sun Ha Jee  ;  Jonathan M. Samet 
Citation
 Diabetes Care, Vol.36(7) : 1988-1993, 2013 
Journal Title
 Diabetes Care 
ISSN
 0149-5992 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism* ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/epidemiology* ; Coronary Disease/blood ; Coronary Disease/epidemiology ; Fasting/blood* ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Stroke/blood ; Stroke/epidemiology
Keywords
Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism* ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/epidemiology* ; Coronary Disease/blood ; Coronary Disease/epidemiology ; Fasting/blood* ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Stroke/blood ; Stroke/epidemiology
Abstract
OBJECTIVE: Although diabetes increases the risk of cardiovascular disease (CVD) and mortality, the dose-response relationship between fasting glucose levels below those diagnostic of diabetes with cardiovascular events has not been well characterized. RESEARCH DESIGN AND METHODS: A prospective cohort study of more than one million Koreans was conducted with a mean follow-up of 16 years. A total of 1,197,384 Korean adults with no specific medical conditions diagnosed were classified by baseline fasting serum glucose level. Associations of fasting glucose level with CVD incidence and mortality, stroke incidence and mortality, and all-cause mortality were analyzed using multivariate proportional hazards regression. RESULTS: The relationships between fasting glucose levels and CVD risks generally followed J-shape curves, with lowest risk in the glucose range of 85-99 mg/dL. As fasting glucose levels increased to >100 mg/dL, risks for CVD, ischemic heart disease, myocardial infarction, and thrombotic stroke progressively increased, but risk for hemorrhagic stroke did not. Fasting glucose levels <70 mg/dL were associated with increased risk of all stroke (hazard ratio 1.06, 95% CI 1.01-1.11) in men and (hazard ratio 1.11, 1.05-1.17) in women. CONCLUSIONS: Both low glucose level and impaired fasting glucose should be considered as predictors of risk for stroke and coronary heart disease. The fasting glucose level associated with the lowest cardiovascular risk may be in a narrow range.
Full Text
http://care.diabetesjournals.org/content/36/7/1988.long
DOI
10.2337/dc12-1577
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Linton, John A.(인요한) ORCID logo https://orcid.org/0000-0001-8000-3049
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88736
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