Cited 108 times in

Fasting Glucose Level and the Risk of Incident Atherosclerotic Cardiovascular Diseases

DC Field Value Language
dc.contributor.author이덕철-
dc.contributor.author인요한-
dc.contributor.author장양수-
dc.contributor.author지선하-
dc.date.accessioned2014-12-18T09:44:24Z-
dc.date.available2014-12-18T09:44:24Z-
dc.date.issued2013-
dc.identifier.issn0149-5992-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88736-
dc.description.abstractOBJECTIVE: Although diabetes increases the risk of cardiovascular disease (CVD) and mortality, the dose-response relationship between fasting glucose levels below those diagnostic of diabetes with cardiovascular events has not been well characterized. RESEARCH DESIGN AND METHODS: A prospective cohort study of more than one million Koreans was conducted with a mean follow-up of 16 years. A total of 1,197,384 Korean adults with no specific medical conditions diagnosed were classified by baseline fasting serum glucose level. Associations of fasting glucose level with CVD incidence and mortality, stroke incidence and mortality, and all-cause mortality were analyzed using multivariate proportional hazards regression. RESULTS: The relationships between fasting glucose levels and CVD risks generally followed J-shape curves, with lowest risk in the glucose range of 85-99 mg/dL. As fasting glucose levels increased to >100 mg/dL, risks for CVD, ischemic heart disease, myocardial infarction, and thrombotic stroke progressively increased, but risk for hemorrhagic stroke did not. Fasting glucose levels <70 mg/dL were associated with increased risk of all stroke (hazard ratio 1.06, 95% CI 1.01-1.11) in men and (hazard ratio 1.11, 1.05-1.17) in women. CONCLUSIONS: Both low glucose level and impaired fasting glucose should be considered as predictors of risk for stroke and coronary heart disease. The fasting glucose level associated with the lowest cardiovascular risk may be in a narrow range.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfDIABETES CARE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBlood Glucose/metabolism*-
dc.subject.MESHCardiovascular Diseases/blood*-
dc.subject.MESHCardiovascular Diseases/epidemiology*-
dc.subject.MESHCoronary Disease/blood-
dc.subject.MESHCoronary Disease/epidemiology-
dc.subject.MESHFasting/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke/blood-
dc.subject.MESHStroke/epidemiology-
dc.titleFasting Glucose Level and the Risk of Incident Atherosclerotic Cardiovascular Diseases-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorChanshin Park-
dc.contributor.googleauthorEliseo Guallar-
dc.contributor.googleauthorJohn A. Linton-
dc.contributor.googleauthorDuk-Chul Lee-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorDong Koog Son-
dc.contributor.googleauthorEun-Jeong Han-
dc.contributor.googleauthorSoo Jin Baek-
dc.contributor.googleauthorYoung Duk Yun-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorJonathan M. Samet-
dc.identifier.doi10.2337/dc12-1577-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02716-
dc.contributor.localIdA03352-
dc.contributor.localIdA03448-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00721-
dc.identifier.eissn1935-5548-
dc.identifier.pmid23404299-
dc.identifier.urlhttp://care.diabetesjournals.org/content/36/7/1988.long-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordBlood Glucose/metabolism*-
dc.subject.keywordCardiovascular Diseases/blood*-
dc.subject.keywordCardiovascular Diseases/epidemiology*-
dc.subject.keywordCoronary Disease/blood-
dc.subject.keywordCoronary Disease/epidemiology-
dc.subject.keywordFasting/blood*-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordProspective Studies-
dc.subject.keywordRisk Factors-
dc.subject.keywordStroke/blood-
dc.subject.keywordStroke/epidemiology-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLinton, John A.-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorLinton, John A.-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsnot free-
dc.citation.volume36-
dc.citation.number7-
dc.citation.startPage1988-
dc.citation.endPage1993-
dc.identifier.bibliographicCitationDIABETES CARE, Vol.36(7) : 1988-1993, 2013-
dc.identifier.rimsid33581-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > International Health Care Center (국제진료소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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