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Study of peripheral BRAFV600E mutation as a possible novel marker for papillary thyroid carcinomas

Authors
 Jin Young Kwak  ;  Jong Ju Jeong  ;  Sang–Wook Kang  ;  Seulkee Park  ;  Jong Rak Choi  ;  Seo–Jin Park  ;  Eun Kyung Kim  ;  Woong Youn Chung 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.35(11) : 1630-1633, 2013 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2013
MeSH
Adult ; Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics* ; Carcinoma/blood ; Carcinoma/genetics* ; Carcinoma/surgery ; Carcinoma, Papillary ; Cohort Studies ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Mutation* ; Prognosis ; Prospective Studies ; Proto-Oncogene Proteins B-raf/genetics* ; Real-Time Polymerase Chain Reaction/methods ; Risk Assessment ; Sensitivity and Specificity ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods ; Young Adult
Keywords
BRAFV600E mutation ; papillary thyroid cancer ; serologic biomarker ; thyroid cancer ; tumor marker
Abstract
BACKGROUND: The BRAF(V600E) mutation can be detected peripherally in the serum of patients with thyroid cancer. The purpose of this study was to establish the value of detecting the peripheral BRAF(V600E) mutation as a serum tumor marker in this population. METHODS: In this study, we obtained 94 serum samples from patients with papillary thyroid cancer positive for the BRAF(V600E) mutation in the tumor itself. The serum samples were analyzed for BRAF(V600E) mutation using real-time polymerase chain reaction (PCR). RESULTS: Sixty-seven patients (71.3%) had papillary thyroid microcarcinoma and 26 patients (27.7%) had underlying lymphocytic thyroiditis. Forty-three patients (45.7%) were found to have stage III or stage IV thyroid cancer. None of the patients had a detectable serum BRAF(V600E) mutation. CONCLUSION: We were unable to identify peripheral BRAF(V600E) mutations in patients with papillary thyroid cancer using real-time PCR. Further studies will be needed to validate our results using various diagnostic methods.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.23195/abstract
DOI
10.1002/hed.23195
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Park, Seo Jin(박서진)
Park, Seul Kee(박슬기) ORCID logo https://orcid.org/0000-0002-7639-1015
Chung, Woung Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88445
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