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Study of peripheral BRAFV600E mutation as a possible novel marker for papillary thyroid carcinomas

DC FieldValueLanguage
dc.contributor.author박슬기-
dc.contributor.author정웅윤-
dc.contributor.author정종주-
dc.contributor.author최종락-
dc.contributor.author강상욱-
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author박서진-
dc.date.accessioned2014-12-18T09:35:06Z-
dc.date.available2014-12-18T09:35:06Z-
dc.date.issued2013-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88445-
dc.description.abstractBACKGROUND: The BRAF(V600E) mutation can be detected peripherally in the serum of patients with thyroid cancer. The purpose of this study was to establish the value of detecting the peripheral BRAF(V600E) mutation as a serum tumor marker in this population. METHODS: In this study, we obtained 94 serum samples from patients with papillary thyroid cancer positive for the BRAF(V600E) mutation in the tumor itself. The serum samples were analyzed for BRAF(V600E) mutation using real-time polymerase chain reaction (PCR). RESULTS: Sixty-seven patients (71.3%) had papillary thyroid microcarcinoma and 26 patients (27.7%) had underlying lymphocytic thyroiditis. Forty-three patients (45.7%) were found to have stage III or stage IV thyroid cancer. None of the patients had a detectable serum BRAF(V600E) mutation. CONCLUSION: We were unable to identify peripheral BRAF(V600E) mutations in patients with papillary thyroid cancer using real-time PCR. Further studies will be needed to validate our results using various diagnostic methods.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/analysis-
dc.subject.MESHBiomarkers, Tumor/genetics*-
dc.subject.MESHCarcinoma/blood-
dc.subject.MESHCarcinoma/genetics*-
dc.subject.MESHCarcinoma/surgery-
dc.subject.MESHCarcinoma, Papillary-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation*-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics*-
dc.subject.MESHReal-Time Polymerase Chain Reaction/methods-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHThyroid Neoplasms/blood-
dc.subject.MESHThyroid Neoplasms/genetics*-
dc.subject.MESHThyroid Neoplasms/surgery-
dc.subject.MESHThyroidectomy/methods-
dc.subject.MESHYoung Adult-
dc.titleStudy of peripheral BRAFV600E mutation as a possible novel marker for papillary thyroid carcinomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJin Young Kwak-
dc.contributor.googleauthorJong Ju Jeong-
dc.contributor.googleauthorSang–Wook Kang-
dc.contributor.googleauthorSeulkee Park-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorSeo–Jin Park-
dc.contributor.googleauthorEun Kyung Kim-
dc.contributor.googleauthorWoong Youn Chung-
dc.identifier.doi10.1002/hed.23195-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01548-
dc.contributor.localIdA03674-
dc.contributor.localIdA03722-
dc.contributor.localIdA04182-
dc.contributor.localIdA00032-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA01494-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid23161556-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/hed.23195/abstract-
dc.subject.keywordBRAFV600E mutation-
dc.subject.keywordpapillary thyroid cancer-
dc.subject.keywordserologic biomarker-
dc.subject.keywordthyroid cancer-
dc.subject.keywordtumor marker-
dc.contributor.alternativeNamePark, Seul Kee-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.alternativeNameJeong, Jong Ju-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.alternativeNameKang, Sang Wook-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNamePark, Seo Jin-
dc.contributor.affiliatedAuthorPark, Seul Kee-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.contributor.affiliatedAuthorJeong, Jong Ju-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.contributor.affiliatedAuthorKang, Sang Wook-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorPark, Seo Jin-
dc.rights.accessRightsnot free-
dc.citation.volume35-
dc.citation.number11-
dc.citation.startPage1630-
dc.citation.endPage1633-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.35(11) : 1630-1633, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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