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Hemoconcentration is a good prognostic predictor for clinical outcomes in acute heart failure: data from the Korean Heart Failure (KorHF) Registry

 Jaewon Oh  ;  Seok-Min Kang  ;  Namki Hong  ;  Jong-Chan Youn  ;  Seongwoo Han  ;  Eun-Seok Jeon  ;  Myeong-Chan Cho  ;  Jae-Joong Kim  ;  Byung-Su Yoo  ;  Shung Chull Chae  ;  Byung-Hee Oh  ;  Dong-Ju Choi  ;  Myung-Mook Lee  ;  Kyu-Hyung Ryu 
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.168(5) : 4739-4743, 2013 
Journal Title
Issue Date
Acute Disease ; Aged ; Biomarkers/blood* ; Cause of Death/trends ; Diuretics/therapeutic use* ; Female ; Follow-Up Studies ; Heart Failure/blood* ; Heart Failure/drug therapy ; Heart Failure/mortality ; Hematocrit ; Hemoglobins/metabolism* ; Humans ; Male ; Patient Readmission/trends ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Registries* ; Republic of Korea/epidemiology ; Survival Rate/trends ; Time Factors
Acute heart failure ; Hemoconcentration ; Prognosis
BACKGROUND: Hemoconcentration is a surrogate marker of effective decongestion and diuresis therapy. Recently, hemoconcentration has been associated with decreased mortality and rehospitalization in heart failure (HF) patients. However, the prognostic power of hemoconcentration in a large sample-sized HF cohort was limited until now. METHODS AND RESULTS: We analyzed data from hospitalized patients with acute heart failure (AHF) that were enrolled in the Korean Heart Failure Registry(n=2,357). The primary end point was a composite of all-cause mortality and HF rehospitalization during the follow-up period (median=347, interquartile range=78-744 days).Hemoconcentration, defined as an increased hemoglobin level between admission and discharge, was presented in 1,016 AHF patients (43.1%). In multivariable logistic regression, hemoglobin, total cholesterol, and serum glucose levels at admission, and ischemic HF, were significant determinants for hemoconcentration occurrence. The Kaplan-Meier curve showed that event-free survival was significantly higher in the hemoconcentration group compared to the non-hemoconcentration group (65.1% vs. 58.1%, log rank p<0.001). In multiple Cox proportional hazard analysis, hemoconcentration was an independent predictor of the primary end point after adjusting for other HF risk factors (hazard ratio=0.671, 95% confidence interval=0.564-0.798, p<0.001). CONCLUSIONS: Hemoconcentration during hospitalization was a prognostic marker of fewer clinical events in the AHF cohort. Therefore, this novel surrogate marker will help in the risk stratification of AHF patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Youn, Jong Chan(윤종찬)
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
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