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Disruption of Orbitofronto-Striatal Functional Connectivity Underlies Maladaptive Persistent Behaviors in Alcohol-Dependent Patients

Authors
 Seojung Lee  ;  Eun Lee  ;  Jeonghun Ku  ;  Kang-Jun Yoon  ;  Kee Namkoong  ;  Young-Chul Jung 
Citation
 PSYCHIATRY INVESTIGATION, Vol.10(3) : 266-272, 2013 
Journal Title
 PSYCHIATRY INVESTIGATION 
ISSN
 1738-3684 
Issue Date
2013
Keywords
Alcohol ; Decision-making ; Dorsal striatum ; Medial orbitofrontal cortex ; fMRI
Abstract
OBJECTIVE: Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. METHODS: Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal cortex (mOFC) as a region-of-interest and performed seed-based functional connectivity analysis. RESULTS: Healthy controls were more flexible in adapting an alternative behavioral strategy, which correlated with stronger mOFC-dorsal striatum functional connectivity. In contrast, alcohol dependent patients persisted to the first established behavioral strategy. The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence. CONCLUSION: Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients.
Files in This Item:
T201303627.pdf Download
DOI
10.4306/pi.2013.10.3.266
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Lee, Seo Jung(이서정)
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88228
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