Cited 16 times in
Disruption of Orbitofronto-Striatal Functional Connectivity Underlies Maladaptive Persistent Behaviors in Alcohol-Dependent Patients
DC Field | Value | Language |
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dc.contributor.author | 남궁기 | - |
dc.contributor.author | 이서정 | - |
dc.contributor.author | 이은 | - |
dc.contributor.author | 정영철 | - |
dc.date.accessioned | 2014-12-18T09:28:12Z | - |
dc.date.available | 2014-12-18T09:28:12Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88228 | - |
dc.description.abstract | OBJECTIVE: Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. METHODS: Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal cortex (mOFC) as a region-of-interest and performed seed-based functional connectivity analysis. RESULTS: Healthy controls were more flexible in adapting an alternative behavioral strategy, which correlated with stronger mOFC-dorsal striatum functional connectivity. In contrast, alcohol dependent patients persisted to the first established behavioral strategy. The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence. CONCLUSION: Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Disruption of Orbitofronto-Striatal Functional Connectivity Underlies Maladaptive Persistent Behaviors in Alcohol-Dependent Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Seojung Lee | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Jeonghun Ku | - |
dc.contributor.googleauthor | Kang-Jun Yoon | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.contributor.googleauthor | Young-Chul Jung | - |
dc.identifier.doi | 10.4306/pi.2013.10.3.266 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03656 | - |
dc.contributor.localId | A01240 | - |
dc.contributor.localId | A02849 | - |
dc.contributor.localId | A03032 | - |
dc.relation.journalcode | J02569 | - |
dc.identifier.eissn | 1976-3026 | - |
dc.identifier.pmid | 24302950 | - |
dc.subject.keyword | Alcohol | - |
dc.subject.keyword | Decision-making | - |
dc.subject.keyword | Dorsal striatum | - |
dc.subject.keyword | Medial orbitofrontal cortex | - |
dc.subject.keyword | fMRI | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.alternativeName | Lee, Seo Jung | - |
dc.contributor.alternativeName | Lee, Eun | - |
dc.contributor.alternativeName | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Lee, Seo Jung | - |
dc.contributor.affiliatedAuthor | Lee, Eun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 266 | - |
dc.citation.endPage | 272 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, Vol.10(3) : 266-272, 2013 | - |
dc.identifier.rimsid | 33137 | - |
dc.type.rims | ART | - |
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