Cited 20 times in
π-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 임은경 | - |
dc.contributor.author | 최유나 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-18T09:24:56Z | - |
dc.date.available | 2014-12-18T09:24:56Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88127 | - |
dc.description.abstract | Molecular targeted delivery of therapeutic agents and their stimuli-responsive release are some of the major issues for modern medical administration, particularly in cancer chemotherapy. In this study, we developed a π-hyaluronan nanocarrier (πHNC) for CD44-targeted and pH-boosted delivery of an aromatic anticancer drug to cancer cells. Amphiphilic π-hyaluronan (pyrenyl hyaluronan, πHA) was synthesized using EDC chemistry, and self-assembled to form πHNC, the structure of which was obviously micellar but was convincingly effective to function; (i) a π-rich pyrenyl core of πHNC, a loading aromatic drug (doxorubicin, DOX) by π-stacking attraction, showed a rapid release profile under low pH conditions which is a notable characteristic of the cancer microenvironment as well as the endolysosomal state after uptake into the target cell and (ii) the hydrophilic hyaluronan shell of πHNC acted as a ligand for CD44 resulting in the localization of πHNC into the target cell by CD44-mediated endocytosis, without cytotoxicity. With its targeted and stimulated delivery of aromatic drugs to the target cells, DOX-loaded πHNC (πHNC/DOX) provided effectual therapeutic activity in both in vitro and in vivo models of CD44-positive human gastric cancer, which is suitable as a facile and efficient drug delivery platform. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | π-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Eunjung Kim | - |
dc.contributor.googleauthor | Hyun-Ouk Kim | - |
dc.contributor.googleauthor | Dong-Joo Kim | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1039/C3TB20906G | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A03391 | - |
dc.contributor.localId | A04130 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J01573 | - |
dc.identifier.eissn | 2050-7518 | - |
dc.identifier.url | http://pubs.rsc.org/EN/content/articlelanding/2013/tb/c3tb20906g#!divAbstract | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Lim, Eun Kyung | - |
dc.contributor.alternativeName | Choi, Yu Na | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lim, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Choi, Yu Na | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 1 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 5686 | - |
dc.citation.endPage | 5693 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, Vol.1(41) : 5686-5693, 2013 | - |
dc.identifier.rimsid | 33071 | - |
dc.type.rims | ART | - |
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