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Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis Read More: http://informahealthcare.com/doi/abs/10.3109/00207454.2012.758120

Authors
 So Yeong Cheon  ;  Kyoung Joo Cho  ;  Jong Eun Lee  ;  Hyun Woo Kim  ;  Su Kyoung Lee  ;  Hyun Jeong Kim  ;  Gyung Whan Kim 
Citation
 INTERNATIONAL JOURNAL OF NEUROSCIENCE, Vol.123(4) : 269-277, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF NEUROSCIENCE 
ISSN
 0020-7454 
Issue Date
2013
MeSH
Animals ; Apoptosis/drug effects* ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism* ; Brain Ischemia/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Neuroprotective Agents/pharmacology* ; Neuroprotective Agents/therapeutic use ; Oxidative Stress/drug effects* ; Panax* ; Plant Extracts/pharmacology* ; Plant Extracts/therapeutic use ; Reactive Oxygen Species/metabolism ; Recovery of Function/drug effects ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism* ; Reperfusion Injury/pathology
Keywords
cerebral ischemia ; apoptosis signal-regulating kinase 1 ; ischemic penumbra
Abstract
Panax ginseng C.A. Meyer has been traditionally used as a medicinal plant and has beneficial effects due to pharmacological properties. Although ginseng is thought to be protective under abnormal conditions, the effects of pretreatment with red ginseng (RG) extract on ischemic stroke have not been fully elucidated. We investigated the protective effects of RG extract after focal cerebral ischemia in mice. Crude RG extract (360 mg/kg) was administered intraperitoneally for 2 weeks. Mice were then subjected to occlusion of the middle cerebral artery for 1 hour, followed by reperfusion for 4 and 24 hours. Pretreatment with RG extract followed by ischemia/reperfusion (I/R) resulted in significant reduction of oxidized hydroethidine signals in ischemic areas. At 4 and 24 hours after I/R, the number of 8-hydroxyguanosine and apoptosis signal-regulating kinase 1 (ASK1)-positive cells decreased in the ischemic penumbra as seen using immunofluorescent staining. Western blotting showed that RG efficiently attenuated the protein levels of activated ASK1 in the ischemic penumbra. Consequently, DNA fragmentation and the infarct volume were reduced by RG extract pretreatment 24 hours after I/R. Also, RG extract resulted in better performance in rotarod test after I/R. Thus, RG pretreatment demonstrates a protective effect at suppressing ischemia-induced oxidative stress and apoptosis in ischemic lesions. Pretreatment with crude RG extract may be an effective strategy for preventing brain injury after an ischemic stroke.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00207454.2012.758120
DOI
10.3109/00207454.2012.758120
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gyung Whan(김경환) ORCID logo https://orcid.org/0000-0001-7053-4372
Kim, Hyun Woo(김현우)
Kim, Hyun Jeong(김현정)
Lee, Su Kyoung(이수경)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Cheon, So Yeong(전소영)
Cho, Kyuong Joo(조경주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88117
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