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Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia

 Young-Chul Yoo  ;  Kyung-Jong Yoo  ;  Beom Jin Lim  ;  Ji-Hae Jun  ;  Jae-Kwang Shim  ;  Young-Lan Kwak 
 JOURNAL OF SURGICAL RESEARCH, Vol.183(2) : 783-791, 2013 
Journal Title
Issue Date
Anesthetics, Intravenous/pharmacology ; Anesthetics, Intravenous/therapeutic use ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use* ; Comorbidity ; Disease Models, Animal ; Etomidate/pharmacology ; Etomidate/therapeutic use ; Hyperglycemia/epidemiology* ; Hyperglycemia/metabolism ; Interleukin-1beta/metabolism ; Kidney/blood supply* ; Kidney/drug effects ; Kidney/metabolism* ; Kidney Tubules/drug effects ; Kidney Tubules/metabolism ; Male ; NF-kappa B/metabolism ; Peroxidase/metabolism ; Propofol/pharmacology ; Propofol/therapeutic use* ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/epidemiology* ; Reperfusion Injury/metabolism ; Reperfusion Injury/prevention & control* ; Superoxide Dismutase/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Antioxidation ; Hyperglycemia ; Inflammation ; Ischemia/reperfusion ; Kidney ; Propofol
BACKGROUND: Hyperglycemia exacerbates renal ischemia-reperfusion (IR) injury via aggravated inflammatory response and excessive production of reactive oxygen species. This study aimed to investigate the ability of propofol, a known antioxidant, to protect kidneys against IR injury in hyperglycemic rats in comparison with normoglycemic rats. METHODS: Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol. Anesthesia was provided with propofol or etomidate depending on the group. Also, the rats received 1.2 g/kg dextrose or the same volume of normal saline depending on the group. Renal ischemia was induced for 25 min. The rats were killed, and samples were collected 65 min after starting intravenous anesthetics (sham) and 15 min and 24 h after reperfusion injury to compare the histologic degree of renal tubular damage and levels of inflammatory markers and enzymes related to reactive oxygen species. RESULTS: Compared with etomidate, propofol significantly attenuated tubular damage after reperfusion in hyperglycemic rats. Also, tubular damage was greater under hyperglycemia compared with normoglycemia in the etomidate group, whereas it was similar in the propofol group. Propofol preserved superoxide dismutase level and attenuated the increase in levels of myeloperoxidase, interlukin-1β, and tumor necrosis factor-α after reperfusion compared with etomidate especially in hyperglycemic rats. Propofol also attenuated the production of inducible nitric oxide synthase and phosphorylation of inhibitor of κB and nuclear factor-κB after reperfusion, which were more prominent under hyperglycemia. CONCLUSIONS: Propofol conveyed renoprotection against IR injury by preserved antioxidation ability and attenuated inflammatory response, which were more prominent under hyperglycemia.
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Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Jun, Ji Hae(전지혜) ORCID logo https://orcid.org/0000-0002-8080-0715
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