Cited 32 times in
Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 유경종 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 전지혜 | - |
dc.date.accessioned | 2014-12-18T09:01:06Z | - |
dc.date.available | 2014-12-18T09:01:06Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0022-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87378 | - |
dc.description.abstract | BACKGROUND: Hyperglycemia exacerbates renal ischemia-reperfusion (IR) injury via aggravated inflammatory response and excessive production of reactive oxygen species. This study aimed to investigate the ability of propofol, a known antioxidant, to protect kidneys against IR injury in hyperglycemic rats in comparison with normoglycemic rats. METHODS: Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol. Anesthesia was provided with propofol or etomidate depending on the group. Also, the rats received 1.2 g/kg dextrose or the same volume of normal saline depending on the group. Renal ischemia was induced for 25 min. The rats were killed, and samples were collected 65 min after starting intravenous anesthetics (sham) and 15 min and 24 h after reperfusion injury to compare the histologic degree of renal tubular damage and levels of inflammatory markers and enzymes related to reactive oxygen species. RESULTS: Compared with etomidate, propofol significantly attenuated tubular damage after reperfusion in hyperglycemic rats. Also, tubular damage was greater under hyperglycemia compared with normoglycemia in the etomidate group, whereas it was similar in the propofol group. Propofol preserved superoxide dismutase level and attenuated the increase in levels of myeloperoxidase, interlukin-1β, and tumor necrosis factor-α after reperfusion compared with etomidate especially in hyperglycemic rats. Propofol also attenuated the production of inducible nitric oxide synthase and phosphorylation of inhibitor of κB and nuclear factor-κB after reperfusion, which were more prominent under hyperglycemia. CONCLUSIONS: Propofol conveyed renoprotection against IR injury by preserved antioxidation ability and attenuated inflammatory response, which were more prominent under hyperglycemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anesthetics, Intravenous/pharmacology | - |
dc.subject.MESH | Anesthetics, Intravenous/therapeutic use | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antioxidants/pharmacology | - |
dc.subject.MESH | Antioxidants/therapeutic use* | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Etomidate/pharmacology | - |
dc.subject.MESH | Etomidate/therapeutic use | - |
dc.subject.MESH | Hyperglycemia/epidemiology* | - |
dc.subject.MESH | Hyperglycemia/metabolism | - |
dc.subject.MESH | Interleukin-1beta/metabolism | - |
dc.subject.MESH | Kidney/blood supply* | - |
dc.subject.MESH | Kidney/drug effects | - |
dc.subject.MESH | Kidney/metabolism* | - |
dc.subject.MESH | Kidney Tubules/drug effects | - |
dc.subject.MESH | Kidney Tubules/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Peroxidase/metabolism | - |
dc.subject.MESH | Propofol/pharmacology | - |
dc.subject.MESH | Propofol/therapeutic use* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Reperfusion Injury/epidemiology* | - |
dc.subject.MESH | Reperfusion Injury/metabolism | - |
dc.subject.MESH | Reperfusion Injury/prevention & control* | - |
dc.subject.MESH | Superoxide Dismutase/metabolism | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.title | Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Young-Chul Yoo | - |
dc.contributor.googleauthor | Kyung-Jong Yoo | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Ji-Hae Jun | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1016/j.jss.2013.02.017 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03551 | - |
dc.relation.journalcode | J01763 | - |
dc.identifier.eissn | 1095-8673 | - |
dc.identifier.pmid | 23498343 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022480413001029 | - |
dc.subject.keyword | Antioxidation | - |
dc.subject.keyword | Hyperglycemia | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Ischemia/reperfusion | - |
dc.subject.keyword | Kidney | - |
dc.subject.keyword | Propofol | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Yoo, Young Chul | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Jun, Ji Hae | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Yoo, Young Chul | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Jun, Ji Hae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 183 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 783 | - |
dc.citation.endPage | 791 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL RESEARCH, Vol.183(2) : 783-791, 2013 | - |
dc.identifier.rimsid | 33014 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.