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Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

 Byeong-Ju Kwon  ;  Jungsung Kim  ;  Yong Hwa Kim  ;  Mi Hee Lee  ;  Hyun Sook Baek  ;  Dae Hyung Lee  ;  Hye-Lee Kim  ;  Hyok Jin Seo  ;  Min Hyeon Lee  ;  Soon-Young Kwon  ;  Min-Ah Koo  ;  Jong-Chul Park 
 ARTIFICIAL ORGANS, Vol.37(7) : 663-670, 2013 
Journal Title
Issue Date
3T3 Cells ; Animals ; Biocompatible Materials* ; Biomechanical Phenomena ; Bone Regeneration* ; Bone Substitutes* ; Bone Transplantation/methods* ; Cell Adhesion ; Cell Culture Techniques ; Cell Survival/drug effects ; Dermatitis, Irritant/etiology ; Dermatitis, Irritant/pathology ; Durapatite/chemistry* ; Durapatite/toxicity ; Feasibility Studies ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Guinea Pigs ; Hemolysis/drug effects ; Materials Testing ; Mice ; Osseointegration ; Porosity ; Rabbits ; Skin Irritancy Tests ; Stress, Mechanical ; Tibia/pathology ; Tibia/surgery* ; Tissue Engineering/methods* ; Tissue Scaffolds*
Biocompatibility ; Polymer replication method ; Porous hydroxyapatite scaffold ; Solid freeform fabrication
Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of physical and mechanical properties of scaffold. The suggested three-dimensional model has interconnected cubic pores of 500 μm and its calculated porosity is 25%. Whereas hydroxyapatite scaffolds fabricated by SFF had connective macropores, those by PRM formed a closed pore external surface with internally interconnected pores. SFF was supposed to be a proper method for fabricating an interconnected macroporous network. Biocompatibility was confirmed by testing the cytotoxicity, hemolysis, irritation, sensitization, and implantation. In summary, the aim was to verify the safety and efficacy of the scaffolds by biomechanical and biological tests with the hope that this research could promote the feasibility of using the scaffolds as a bone substitute.
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6. Others (기타) > Severance Hospital (세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Kim, Hye Lee(김혜리)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Baek, Hyun Sook(백현숙)
Seo, Hyok Jin(서혁진)
Lee, Dae Hyung(이대형)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
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