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Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration

DC Field Value Language
dc.contributor.author구민아-
dc.contributor.author권병주-
dc.contributor.author김혜리-
dc.contributor.author박종철-
dc.contributor.author백현숙-
dc.contributor.author서혁진-
dc.contributor.author이대형-
dc.contributor.author이미희-
dc.date.accessioned2014-12-18T08:59:03Z-
dc.date.available2014-12-18T08:59:03Z-
dc.date.issued2013-
dc.identifier.issn0160-564X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87317-
dc.description.abstractPresently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of physical and mechanical properties of scaffold. The suggested three-dimensional model has interconnected cubic pores of 500 μm and its calculated porosity is 25%. Whereas hydroxyapatite scaffolds fabricated by SFF had connective macropores, those by PRM formed a closed pore external surface with internally interconnected pores. SFF was supposed to be a proper method for fabricating an interconnected macroporous network. Biocompatibility was confirmed by testing the cytotoxicity, hemolysis, irritation, sensitization, and implantation. In summary, the aim was to verify the safety and efficacy of the scaffolds by biomechanical and biological tests with the hope that this research could promote the feasibility of using the scaffolds as a bone substitute.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfARTIFICIAL ORGANS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH3T3 Cells-
dc.subject.MESHAnimals-
dc.subject.MESHBiocompatible Materials*-
dc.subject.MESHBiomechanical Phenomena-
dc.subject.MESHBone Regeneration*-
dc.subject.MESHBone Substitutes*-
dc.subject.MESHBone Transplantation/methods*-
dc.subject.MESHCell Adhesion-
dc.subject.MESHCell Culture Techniques-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHDermatitis, Irritant/etiology-
dc.subject.MESHDermatitis, Irritant/pathology-
dc.subject.MESHDurapatite/chemistry*-
dc.subject.MESHDurapatite/toxicity-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHFibroblasts/drug effects-
dc.subject.MESHFibroblasts/pathology-
dc.subject.MESHGuinea Pigs-
dc.subject.MESHHemolysis/drug effects-
dc.subject.MESHMaterials Testing-
dc.subject.MESHMice-
dc.subject.MESHOsseointegration-
dc.subject.MESHPorosity-
dc.subject.MESHRabbits-
dc.subject.MESHSkin Irritancy Tests-
dc.subject.MESHStress, Mechanical-
dc.subject.MESHTibia/pathology-
dc.subject.MESHTibia/surgery*-
dc.subject.MESHTissue Engineering/methods*-
dc.subject.MESHTissue Scaffolds*-
dc.titleBiological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorByeong-Ju Kwon-
dc.contributor.googleauthorJungsung Kim-
dc.contributor.googleauthorYong Hwa Kim-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorHyun Sook Baek-
dc.contributor.googleauthorDae Hyung Lee-
dc.contributor.googleauthorHye-Lee Kim-
dc.contributor.googleauthorHyok Jin Seo-
dc.contributor.googleauthorMin Hyeon Lee-
dc.contributor.googleauthorSoon-Young Kwon-
dc.contributor.googleauthorMin-Ah Koo-
dc.contributor.googleauthorJong-Chul Park-
dc.identifier.doi10.1111/aor.12047-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00190-
dc.contributor.localIdA00218-
dc.contributor.localIdA01169-
dc.contributor.localIdA01662-
dc.contributor.localIdA01843-
dc.contributor.localIdA01922-
dc.contributor.localIdA02713-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ00246-
dc.identifier.eissn1525-1594-
dc.identifier.pmid23419084-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aor.12047/abstract-
dc.subject.keywordBiocompatibility-
dc.subject.keywordPolymer replication method-
dc.subject.keywordPorous hydroxyapatite scaffold-
dc.subject.keywordSolid freeform fabrication-
dc.contributor.alternativeNameKoo, Min Ah-
dc.contributor.alternativeNameKwon, Byeong Ju-
dc.contributor.alternativeNameKim, Hye Lee-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameBaek, Hyun Sook-
dc.contributor.alternativeNameSeo, Hyok Jin-
dc.contributor.alternativeNameLee, Dae Hyung-
dc.contributor.alternativeNameLee, Mi Hee-
dc.contributor.affiliatedAuthorKoo, Min Ah-
dc.contributor.affiliatedAuthorKwon, Byeong Ju-
dc.contributor.affiliatedAuthorKim, Hye Lee-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorBaek, Hyun Sook-
dc.contributor.affiliatedAuthorSeo, Hyok Jin-
dc.contributor.affiliatedAuthorLee, Dae Hyung-
dc.contributor.affiliatedAuthorLee, Mi Hee-
dc.rights.accessRightsnot free-
dc.citation.volume37-
dc.citation.number7-
dc.citation.startPage663-
dc.citation.endPage670-
dc.identifier.bibliographicCitationARTIFICIAL ORGANS, Vol.37(7) : 663-670, 2013-
dc.identifier.rimsid32976-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Severance Hospital (세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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