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Quantitative Assessment of Aortic Elasticity With Aging Using Velocity-Vector Imaging and Its Histologic Correlation

Authors
 Sung-Ai Kim  ;  Kyung Hye Lee  ;  Ho-Yeon Won  ;  Sungha Park  ;  Ji Hyung Chung  ;  Yangsoo Jang  ;  Jong-Won Ha 
Citation
 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.33(6) : 1306-1312, 2013 
Journal Title
 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 
ISSN
 1079-5642 
Issue Date
2013
MeSH
Aging/physiology* ; Animals ; Aorta/diagnostic imaging* ; Aorta/pathology* ; Biopsy, Needle ; Dogs ; Elasticity/physiology* ; Evaluation Studies as Topic ; Female ; Immunohistochemistry ; Models, Animal ; Pulse Wave Analysis/methods* ; Reproducibility of Results ; Ultrasonography ; Vascular Stiffness
Keywords
aging ; aorta ; collagen ; elasticity ; velocity-vector imaging
Abstract
OBJECTIVE: Velocity-vector imaging (VVI) represents a valuable new method for noninvasive quantification of vascular properties associated with aging. The purpose of this study was to assess the correlations between VVI parameters and histological changes with aging. APPROACH AND RESULTS: Fourteen mongrel dogs were classified as either young (n=7; age, 1-2 years; female; weighing 22-29 kg) or senescent (n=7; age, 8-12 years; female; weighing 36-45 kg). The short-axis image of the descending thoracic aorta was obtained for VVI analysis with transesophageal echocardiography. The location of the image was identified using fluoroscopic guidance, and the aortic tissue was extracted. After dividing the aortic wall into 6 segments, both regional and segmental tissue collagen and elastin contents were quantified and correlated with the aortic elastic properties. In the regional analysis, the M-mode-derived aortic dimensions and elastic moduli except for intima-media thickness were not significantly different between the groups, whereas the VVI-derived aortic area and fractional area changes showed more dilated and stiffer aorta in senescent dogs. Also, fractional area change was significantly correlated with the tissue collagen content unlike the M-mode-derived elastic moduli. In the segmental analysis, the radial velocity, circumferential strain, and strain rates of VVI were more reduced in senescent dogs than young dogs, and the radial velocity and circumferential strain showed independent associations with the collagen content of the corresponding aortic wall. CONCLUSIONS: VVI was a feasible method for direct quantification of aortic elastic properties with a significant histological correlation.
Full Text
http://atvb.ahajournals.org/content/33/6/1306.long
DOI
10.1161/ATVBAHA.113.301312
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Won, Ho Youn(원호연)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Ji Hyung(정지형)
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87267
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