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Quantitative Assessment of Aortic Elasticity With Aging Using Velocity-Vector Imaging and Its Histologic Correlation

DC Field Value Language
dc.contributor.author박성하-
dc.contributor.author원호연-
dc.contributor.author장양수-
dc.contributor.author정지형-
dc.contributor.author하종원-
dc.date.accessioned2014-12-18T08:57:28Z-
dc.date.available2014-12-18T08:57:28Z-
dc.date.issued2013-
dc.identifier.issn1079-5642-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87267-
dc.description.abstractOBJECTIVE: Velocity-vector imaging (VVI) represents a valuable new method for noninvasive quantification of vascular properties associated with aging. The purpose of this study was to assess the correlations between VVI parameters and histological changes with aging. APPROACH AND RESULTS: Fourteen mongrel dogs were classified as either young (n=7; age, 1-2 years; female; weighing 22-29 kg) or senescent (n=7; age, 8-12 years; female; weighing 36-45 kg). The short-axis image of the descending thoracic aorta was obtained for VVI analysis with transesophageal echocardiography. The location of the image was identified using fluoroscopic guidance, and the aortic tissue was extracted. After dividing the aortic wall into 6 segments, both regional and segmental tissue collagen and elastin contents were quantified and correlated with the aortic elastic properties. In the regional analysis, the M-mode-derived aortic dimensions and elastic moduli except for intima-media thickness were not significantly different between the groups, whereas the VVI-derived aortic area and fractional area changes showed more dilated and stiffer aorta in senescent dogs. Also, fractional area change was significantly correlated with the tissue collagen content unlike the M-mode-derived elastic moduli. In the segmental analysis, the radial velocity, circumferential strain, and strain rates of VVI were more reduced in senescent dogs than young dogs, and the radial velocity and circumferential strain showed independent associations with the collagen content of the corresponding aortic wall. CONCLUSIONS: VVI was a feasible method for direct quantification of aortic elastic properties with a significant histological correlation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAging/physiology*-
dc.subject.MESHAnimals-
dc.subject.MESHAorta/diagnostic imaging*-
dc.subject.MESHAorta/pathology*-
dc.subject.MESHBiopsy, Needle-
dc.subject.MESHDogs-
dc.subject.MESHElasticity/physiology*-
dc.subject.MESHEvaluation Studies as Topic-
dc.subject.MESHFemale-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHModels, Animal-
dc.subject.MESHPulse Wave Analysis/methods*-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHUltrasonography-
dc.subject.MESHVascular Stiffness-
dc.titleQuantitative Assessment of Aortic Elasticity With Aging Using Velocity-Vector Imaging and Its Histologic Correlation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSung-Ai Kim-
dc.contributor.googleauthorKyung Hye Lee-
dc.contributor.googleauthorHo-Yeon Won-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorJi Hyung Chung-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorJong-Won Ha-
dc.identifier.doi10.1161/ATVBAHA.113.301312-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01512-
dc.contributor.localIdA02448-
dc.contributor.localIdA03448-
dc.contributor.localIdA03739-
dc.contributor.localIdA04257-
dc.relation.journalcodeJ00238-
dc.identifier.eissn1524-4636-
dc.identifier.pmid23580144-
dc.identifier.urlhttp://atvb.ahajournals.org/content/33/6/1306.long-
dc.subject.keywordaging-
dc.subject.keywordaorta-
dc.subject.keywordcollagen-
dc.subject.keywordelasticity-
dc.subject.keywordvelocity-vector imaging-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameWon, Ho Youn-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Ji Hyung-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorWon, Ho Youn-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Ji Hyung-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.rights.accessRightsnot free-
dc.citation.volume33-
dc.citation.number6-
dc.citation.startPage1306-
dc.citation.endPage1312-
dc.identifier.bibliographicCitationARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.33(6) : 1306-1312, 2013-
dc.identifier.rimsid32938-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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