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Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study

Authors
 Dong Hoon Lee  ;  Ji Young Kim  ;  Mi Kyung Lee  ;  Choae Lee  ;  Ji-Hee Min  ;  Duck Hyoun Jeong  ;  Ji-Won Lee  ;  Sang Hui Chu  ;  Jeffrey A. Meyerhardt  ;  Jennifer Ligibel  ;  Lee W. Jones  ;  Nam Kyu Kim  ;  Justin Y. Jeon 
Citation
 Supportive Care in Cancer, Vol.21(9) : 2537-2545, 2013 
Journal Title
 Supportive Care in Cancer 
ISSN
 0941-4355 
Issue Date
2013
Abstract
PURPOSE: The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer. METHODS: Seventeen patients (age 55.18 ± 13.3 years) with stage II-III colorectal cancer completed the 12-week home-based exercise program. Subjects were randomized into either casually intervened home-based exercise group (CIHE) or intensely intervened home-based exercise group (IIHE). The primary outcome was the level of PA. Furthermore, insulin, homeostasis model assessment of insulin resistance, insulin-like growth factor axis, and adipocytokines were measured. RESULTS: Both CIHE and IIHE program significantly increased the level of PA at 12 weeks compared to its level at baseline (CIHE, 10.00 ± 8.49 vs. 46.07 ± 45.59; IIHE, 12.08 ± 11.04 vs. 35.42 ± 27.42 MET hours per week). Since there was no difference in PA change between groups (p = 0.511), the data was combined in analyzing the effects of increased PA on biomarkers. Increase in PA significantly reduced insulin (6.66 ± 4.58 vs. 4.86 ± 3.48 μU/ml, p = 0.006), HOMA-IR (1.66 ± 1.23 vs. 1.25 ± 1.04, p = 0.017), and tumor necrosis alpha-α (TNF-α 4.85 ± 7.88 vs. 2.95 ± 5.38 pg/ml, p = 0.004), and significantly increased IGF-1 (135.39 ± 60.15 vs. 159.53 ng/ml, p = 0.007), IGF binding protein (IGFBP)-3 (2.67 ± 1.48 vs. 3.48 ± 1.00 ng/ml, p = 0.013), and adiponectin (6.73 ± 3.07 vs. 7.54 ± 3.96 μg/ml, p = 0.015). CONCLUSION: CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II-III colorectal cancer survivors.
Full Text
http://dx.doi.org/10.1007/s00520-013-1822-7
DOI
10.1007/s00520-013-1822-7
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
정덕현(Jeong, Duck Hyoun)
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87214
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