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Continuous Coaxial Electrohydrodynamic Atomization System for Water-Stable Wrapping of Magnetic Nanoparticles

Authors
 Sang-Yoon Kim  ;  Jaemoon Yang  ;  Bongjune Kim  ;  Jungmin Park  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam  ;  Jungho Hwang 
Citation
 SMALL, Vol.9(13) : 2325-2330, 2013 
Journal Title
SMALL
ISSN
 1613-6810 
Issue Date
2013
Keywords
electrohydrodynamic atomization ; encapsulation ; magnetic materials ; magnetic resonance imaging ; nanoparticles
Abstract
An electrohydrodynamic atomization (EHDA) system that generates an electrospray can achieve particle formation and encapsulation by accumulating an electric charge on liquid flowing out from the nozzle. A novel coaxial EHDA system for continuous fabrication of water-stable magnetic nanoparticles (MNPs) is established, based on a cone-jet mode of electrospraying. Systemic variables, such as flow rates from dual nozzles and inducing voltages, are controlled to enable the preparation of water-soluble MNPs coated by polysorbate 80. The PEGylated MNPs exhibit water stability. The magnetic resonance imaging potential of these MNPs is confirmed by in vivo imaging using a gastric cancer xenograft mouse model. Thus, this advanced coaxial EHDA system demonstrates remarkable capabilities for the continuous encapsulation of MNPs to render them water-stable while preserving their properties as imaging agents.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/smll.201201553/abstract
DOI
10.1002/smll.201201553
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87155
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