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Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin

Authors
 SUNYOUNG JUNG  ;  SIMON WEONSANG RO  ;  WOO-CHAN SON  ;  EUN-SIL YU  ;  HYE-LIM JU  ;  GEUNYOUNG JUNG 
Citation
 Oncology Reports, Vol.29(4) : 1293-1298, 2013 
Journal Title
 Oncology Reports 
ISSN
 1021-335X 
Issue Date
2013
Abstract
The Sleeping Beauty transposon system is used as a tool for insertional mutagenesis and oncogenesis. However, little is known about the exact histological phenotype of the tumors induced. Thus, we used immunohistochemical markers to enable histological identification of the type of tumor induced by subcutaneous injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor was removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemical markers to histologically identify the tumor type. The results suggested that the morphology of the tumor was similar to that of sarcomatoid carcinoma.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86897
DOI
10.3892/or.2013.2264
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Liver Cirrhosis Clinical Research Center (간경변증임상연구센터)
Yonsei Authors
노원상(Ro, Simon Weonsang) ; 주혜림(Ju, Hye Lim)
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