Cited 8 times in
Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin
DC Field | Value | Language |
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dc.contributor.author | 노원상 | - |
dc.contributor.author | 주혜림 | - |
dc.date.accessioned | 2014-12-18T08:45:27Z | - |
dc.date.available | 2014-12-18T08:45:27Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86897 | - |
dc.description.abstract | The Sleeping Beauty transposon system is used as a tool for insertional mutagenesis and oncogenesis. However, little is known about the exact histological phenotype of the tumors induced. Thus, we used immunohistochemical markers to enable histological identification of the type of tumor induced by subcutaneous injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor was removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemical markers to histologically identify the tumor type. The results suggested that the morphology of the tumor was similar to that of sarcomatoid carcinoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carcinoma/diagnostic imaging | - |
dc.subject.MESH | Carcinoma/pathology* | - |
dc.subject.MESH | Cell Transformation, Neoplastic/genetics | - |
dc.subject.MESH | DNA Transposable Elements/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Subcutaneous | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mutagenesis, Insertional/genetics | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/administration & dosage | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/genetics* | - |
dc.subject.MESH | Proto-Oncogene Proteins p21(ras)/administration & dosage | - |
dc.subject.MESH | Proto-Oncogene Proteins p21(ras)/genetics* | - |
dc.subject.MESH | RNA, Small Interfering/administration & dosage | - |
dc.subject.MESH | RNA, Small Interfering/genetics | - |
dc.subject.MESH | Radiography | - |
dc.subject.MESH | Transposases/genetics* | - |
dc.subject.MESH | Tumor Suppressor Protein p53/genetics* | - |
dc.title | Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | SUNYOUNG JUNG | - |
dc.contributor.googleauthor | SIMON WEONSANG RO | - |
dc.contributor.googleauthor | GEUNYOUNG JUNG | - |
dc.contributor.googleauthor | HYE-LIM JU | - |
dc.contributor.googleauthor | EUN-SIL YU | - |
dc.contributor.googleauthor | WOO-CHAN SON | - |
dc.identifier.doi | 10.3892/or.2013.2264 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03961 | - |
dc.contributor.localId | A01286 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 23380875 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Carcinoma/diagnostic imaging | - |
dc.subject.keyword | Carcinoma/pathology* | - |
dc.subject.keyword | Cell Transformation, Neoplastic/genetics | - |
dc.subject.keyword | DNA Transposable Elements/genetics* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Gene Expression Regulation, Neoplastic | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Injections, Subcutaneous | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred C57BL | - |
dc.subject.keyword | Mutagenesis, Insertional/genetics | - |
dc.subject.keyword | Positron-Emission Tomography | - |
dc.subject.keyword | Proto-Oncogene Proteins c-myc/administration & dosage | - |
dc.subject.keyword | Proto-Oncogene Proteins c-myc/genetics* | - |
dc.subject.keyword | Proto-Oncogene Proteins p21(ras)/administration & dosage | - |
dc.subject.keyword | Proto-Oncogene Proteins p21(ras)/genetics* | - |
dc.subject.keyword | RNA, Small Interfering/administration & dosage | - |
dc.subject.keyword | RNA, Small Interfering/genetics | - |
dc.subject.keyword | Radiography | - |
dc.subject.keyword | Transposases/genetics* | - |
dc.subject.keyword | Tumor Suppressor Protein p53/genetics* | - |
dc.contributor.alternativeName | Ro, Simon Weonsang | - |
dc.contributor.alternativeName | Ju, Hye Lim | - |
dc.contributor.affiliatedAuthor | Ju, Hye Lim | - |
dc.contributor.affiliatedAuthor | Ro, Simon Weonsang | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1293 | - |
dc.citation.endPage | 1298 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.29(4) : 1293-1298, 2013 | - |
dc.identifier.rimsid | 29279 | - |
dc.type.rims | ART | - |
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