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A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect

Authors
 Hyun-Ouk Kim  ;  Eunjung Kim  ;  Yonghee An  ;  Jihye Choi  ;  Eunji Jang  ;  Eun Bi Choi  ;  Aastha Kukreja  ;  Myeong-Hoon Kim  ;  Byunghoon Kang  ;  Dong-Joo Kim  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 MACROMOLECULAR BIOSCIENCE, Vol.13(6) : 745-754, 2013 
Journal Title
 MACROMOLECULAR BIOSCIENCE 
ISSN
 1616-5187 
Issue Date
2013
MeSH
Antineoplastic Agents/pharmacology* ; Apoptosis/drug effects ; Biocompatible Materials/chemistry* ; Cell Line, Tumor ; Cell Survival/drug effects ; Cryoelectron Microscopy ; Doxorubicin/pharmacology* ; Drug Delivery Systems* ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Humans ; Hydrogen-Ion Concentration/drug effects ; Hydrolysis/drug effects ; Inhibitory Concentration 50 ; Kinetics ; Polyesters/chemistry* ; Polyethylene Glycols/chemistry* ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism* ; Time Factors ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism*
Keywords
Antineoplastic Agents/pharmacology* ; Apoptosis/drug effects ; Biocompatible Materials/chemistry* ; Cell Line, Tumor ; Cell Survival/drug effects ; Cryoelectron Microscopy ; Doxorubicin/pharmacology* ; Drug Delivery Systems* ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Humans ; Hydrogen-Ion Concentration/drug effects ; Hydrolysis/drug effects ; Inhibitory Concentration 50 ; Kinetics ; Polyesters/chemistry* ; Polyethylene Glycols/chemistry* ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism* ; Time Factors ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism*
Abstract
Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200448/abstract
DOI
10.1002/mabi.201200448
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86820
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