Cited 46 times in
A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-18T08:42:57Z | - |
dc.date.available | 2014-12-18T08:42:57Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86820 | - |
dc.description.abstract | Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Biocompatible Materials/chemistry* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cryoelectron Microscopy | - |
dc.subject.MESH | Doxorubicin/pharmacology* | - |
dc.subject.MESH | Drug Delivery Systems* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.MESH | Gene Silencing/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydrogen-Ion Concentration/drug effects | - |
dc.subject.MESH | Hydrolysis/drug effects | - |
dc.subject.MESH | Inhibitory Concentration 50 | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Polyesters/chemistry* | - |
dc.subject.MESH | Polyethylene Glycols/chemistry* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | RNA, Small Interfering/metabolism* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | bcl-2-Associated X Protein/genetics | - |
dc.subject.MESH | bcl-2-Associated X Protein/metabolism | - |
dc.subject.MESH | bcl-X Protein/genetics | - |
dc.subject.MESH | bcl-X Protein/metabolism* | - |
dc.title | A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Hyun-Ouk Kim | - |
dc.contributor.googleauthor | Eunjung Kim | - |
dc.contributor.googleauthor | Yonghee An | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Eun Bi Choi | - |
dc.contributor.googleauthor | Aastha Kukreja | - |
dc.contributor.googleauthor | Myeong-Hoon Kim | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Dong-Joo Kim | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1002/mabi.201200448 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02176 | - |
dc.identifier.eissn | 1616-5195 | - |
dc.identifier.pmid | 23613425 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200448/abstract | - |
dc.subject.keyword | Antineoplastic Agents/pharmacology* | - |
dc.subject.keyword | Apoptosis/drug effects | - |
dc.subject.keyword | Biocompatible Materials/chemistry* | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Cell Survival/drug effects | - |
dc.subject.keyword | Cryoelectron Microscopy | - |
dc.subject.keyword | Doxorubicin/pharmacology* | - |
dc.subject.keyword | Drug Delivery Systems* | - |
dc.subject.keyword | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.keyword | Gene Silencing/drug effects | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hydrogen-Ion Concentration/drug effects | - |
dc.subject.keyword | Hydrolysis/drug effects | - |
dc.subject.keyword | Inhibitory Concentration 50 | - |
dc.subject.keyword | Kinetics | - |
dc.subject.keyword | Polyesters/chemistry* | - |
dc.subject.keyword | Polyethylene Glycols/chemistry* | - |
dc.subject.keyword | RNA, Messenger/genetics | - |
dc.subject.keyword | RNA, Messenger/metabolism | - |
dc.subject.keyword | RNA, Small Interfering/metabolism* | - |
dc.subject.keyword | Time Factors | - |
dc.subject.keyword | bcl-2-Associated X Protein/genetics | - |
dc.subject.keyword | bcl-2-Associated X Protein/metabolism | - |
dc.subject.keyword | bcl-X Protein/genetics | - |
dc.subject.keyword | bcl-X Protein/metabolism* | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 745 | - |
dc.citation.endPage | 754 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, Vol.13(6) : 745-754, 2013 | - |
dc.identifier.rimsid | 29225 | - |
dc.type.rims | ART | - |
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