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Added value of subtraction imaging in detecting arterial enhancement in small (<3 cm) hepatic nodules on dynamic contrast-enhanced MRI in patients at high risk of hepatocellular carcinoma

DC Field Value Language
dc.contributor.author김명진-
dc.contributor.author김여은-
dc.contributor.author박미숙-
dc.contributor.author이형진-
dc.contributor.author정우석-
dc.contributor.author김기황-
dc.contributor.author안찬식-
dc.date.accessioned2014-12-18T08:42:24Z-
dc.date.available2014-12-18T08:42:24Z-
dc.date.issued2013-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86803-
dc.description.abstractOBJECTIVES: To determine the importance of arterial enhancement in diagnosing small (<3 cm) hepatocellular carcinomas (HCCs) and to evaluate the added value of dynamic subtraction magnetic resonance imaging (MRI) in detecting arterial enhancement in small (<3 cm) hepatic nodules in high-risk patients. METHODS: Eighty-six patients with 135 pathologically confirmed small (<3 cm) hepatic nodules (104 HCCs, 31 benign nodules) underwent MRI before curative surgery. Arterial enhancement was determined by three methods: (1) visual assessment of the arterial phase alone, (2) visual comparison of the arterial phase with the unenhanced phase and (3) additional review of subtraction images. The diagnostic performance of each method was calculated and compared using generalised estimating equations analysis. RESULTS: Arterial enhancement demonstrated high positive predictive value (PPV) (96.5-98.9 %) and specificity (90.3-96.8 %), but low negative predictive value (NPV) (54.6-62.5 %) and intermediate sensitivity (76-79.8 %) for diagnosing small HCCs. Diagnostic performance was highest for subtraction imaging. There were significant differences among the three methods in sensitivity (P = 0.04), accuracy (P = 0.044), PPV (P < 0.001) and NPV (P = 0.024), but not in specificity (P = 0.167). CONCLUSION: The accurate detection of arterial enhancement in small hepatic nodules is important for diagnosing HCC and may be enhanced by subtraction imaging.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/pathology*-
dc.subject.MESHContrast Media-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium DTPA*-
dc.subject.MESHHepatic Artery/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHImage Enhancement/methods*-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSubtraction Technique*-
dc.titleAdded value of subtraction imaging in detecting arterial enhancement in small (<3 cm) hepatic nodules on dynamic contrast-enhanced MRI in patients at high risk of hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorChansik An-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorDowhan Kim-
dc.contributor.googleauthorYeo-Eun Kim-
dc.contributor.googleauthorWoo-Suk Chung-
dc.contributor.googleauthorHyungjin Rhee-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorKi Whang Kim-
dc.identifier.doi10.1007/s00330-012-2685-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01463-
dc.contributor.localIdA00426-
dc.contributor.localIdA00688-
dc.contributor.localIdA03666-
dc.contributor.localIdA00345-
dc.contributor.localIdA05171-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid23138382-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00330-012-2685-x-
dc.subject.keywordDiagnosis-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordArterial enhancement-
dc.subject.keywordSubtraction technique-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNameKim, Yeo Eun-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.alternativeNameRhee, Hyung Jin-
dc.contributor.alternativeNameChung, Woo Seok-
dc.contributor.alternativeNameKim, Ki Whang-
dc.contributor.affiliatedAuthorPark, Mi-Suk-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorKim, Yeo Eun-
dc.contributor.affiliatedAuthorChung, Woo Seok-
dc.contributor.affiliatedAuthorKim, Ki Whang-
dc.contributor.affiliatedAuthorRhee, Hyungjin-
dc.rights.accessRightsnot free-
dc.citation.volume23-
dc.citation.number4-
dc.citation.startPage924-
dc.citation.endPage930-
dc.identifier.bibliographicCitationEUROPEAN RADIOLOGY, Vol.23(4) : 924-930, 2013-
dc.identifier.rimsid29215-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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