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Proper Indication of BRAFV600E Mutation Testing in Fine-Needle Aspirates of Thyroid Nodules

Authors
 Jieun Koh  ;  Eun-Kyung Kim  ;  Jung Hyun Yoon  ;  Hee Jung Moon  ;  Jin Young Kwak  ;  Jong Rak Choi  ;  Kyung Hwa Han 
Citation
 PLOS ONE, Vol.8(5) : e64505, 2013 
Journal Title
 PLOS ONE 
Issue Date
2013
MeSH
Adult ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Humans ; Middle Aged ; Mutation* ; Proto-Oncogene Proteins B-raf/genetics* ; Reproducibility of Results ; Sensitivity and Specificity ; Thyroid Nodule/diagnosis ; Thyroid Nodule/genetics* ; Thyroid Nodule/pathology*
Keywords
Adult ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Humans ; Middle Aged ; Mutation* ; Proto-Oncogene Proteins B-raf/genetics* ; Reproducibility of Results ; Sensitivity and Specificity ; Thyroid Nodule/diagnosis ; Thyroid Nodule/genetics* ; Thyroid Nodule/pathology*
Abstract
Background The aim of this study was to evaluate the proper indication of adjunctive BRAFV600E mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules. Methods This study included 518 nodules in 479 patients who underwent ultrasound-guided fine-needle aspiration with BRAFV600E mutation. We calculated and compared the diagnostic performances of cytology and cytology with BRAFV600E mutation analysis to detect malignancy among thyroid nodules according to ultrasound features and size. Results Sensitivity, negative predictive value, and accuracy of cytology with BRAFV600E mutation analysis were significantly higher than those of cytology alone in thyroid nodules with suspicious ultrasound features, regardless of size. Diagnostic performances did not show significant differences between cytology and cytology with BRAFV600E mutation analysis in nodules without any suspicious ultrasound features, regardless of size. Conclusion The BRAFV600E mutation analysis was a useful adjunctive diagnostic tool in the diagnosis of thyroid nodules with suspicious ultrasound features regardless of size.
Files in This Item:
T201301371.pdf Download
DOI
10.1371/journal.pone.0064505
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86797
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