Cited 24 times in
Proper Indication of BRAFV600E Mutation Testing in Fine-Needle Aspirates of Thyroid Nodules
DC Field | Value | Language |
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dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 윤정현 | - |
dc.contributor.author | 최종락 | - |
dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2014-12-18T08:42:11Z | - |
dc.date.available | 2014-12-18T08:42:11Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86797 | - |
dc.description.abstract | Background The aim of this study was to evaluate the proper indication of adjunctive BRAFV600E mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules. Methods This study included 518 nodules in 479 patients who underwent ultrasound-guided fine-needle aspiration with BRAFV600E mutation. We calculated and compared the diagnostic performances of cytology and cytology with BRAFV600E mutation analysis to detect malignancy among thyroid nodules according to ultrasound features and size. Results Sensitivity, negative predictive value, and accuracy of cytology with BRAFV600E mutation analysis were significantly higher than those of cytology alone in thyroid nodules with suspicious ultrasound features, regardless of size. Diagnostic performances did not show significant differences between cytology and cytology with BRAFV600E mutation analysis in nodules without any suspicious ultrasound features, regardless of size. Conclusion The BRAFV600E mutation analysis was a useful adjunctive diagnostic tool in the diagnosis of thyroid nodules with suspicious ultrasound features regardless of size. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Endoscopic Ultrasound-Guided Fine Needle Aspiration | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/genetics* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Thyroid Nodule/diagnosis | - |
dc.subject.MESH | Thyroid Nodule/genetics* | - |
dc.subject.MESH | Thyroid Nodule/pathology* | - |
dc.title | Proper Indication of BRAFV600E Mutation Testing in Fine-Needle Aspirates of Thyroid Nodules | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jieun Koh | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Jung Hyun Yoon | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Kyung Hwa Han | - |
dc.identifier.doi | 10.1371/journal.pone.0064505 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A02595 | - |
dc.contributor.localId | A04182 | - |
dc.contributor.localId | A04267 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 23717622 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Endoscopic Ultrasound-Guided Fine Needle Aspiration | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Mutation* | - |
dc.subject.keyword | Proto-Oncogene Proteins B-raf/genetics* | - |
dc.subject.keyword | Reproducibility of Results | - |
dc.subject.keyword | Sensitivity and Specificity | - |
dc.subject.keyword | Thyroid Nodule/diagnosis | - |
dc.subject.keyword | Thyroid Nodule/genetics* | - |
dc.subject.keyword | Thyroid Nodule/pathology* | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.alternativeName | Yoon, Jung Hyun | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.alternativeName | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Yoon, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Han, Kyung Hwa | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e64505 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.8(5) : e64505, 2013 | - |
dc.identifier.rimsid | 29211 | - |
dc.type.rims | ART | - |
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