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Proper Indication of BRAFV600E Mutation Testing in Fine-Needle Aspirates of Thyroid Nodules

DC FieldValueLanguage
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author윤정현-
dc.contributor.author최종락-
dc.contributor.author한경화-
dc.date.accessioned2014-12-18T08:42:11Z-
dc.date.available2014-12-18T08:42:11Z-
dc.date.issued2013-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86797-
dc.description.abstractBackground The aim of this study was to evaluate the proper indication of adjunctive BRAFV600E mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules. Methods This study included 518 nodules in 479 patients who underwent ultrasound-guided fine-needle aspiration with BRAFV600E mutation. We calculated and compared the diagnostic performances of cytology and cytology with BRAFV600E mutation analysis to detect malignancy among thyroid nodules according to ultrasound features and size. Results Sensitivity, negative predictive value, and accuracy of cytology with BRAFV600E mutation analysis were significantly higher than those of cytology alone in thyroid nodules with suspicious ultrasound features, regardless of size. Diagnostic performances did not show significant differences between cytology and cytology with BRAFV600E mutation analysis in nodules without any suspicious ultrasound features, regardless of size. Conclusion The BRAFV600E mutation analysis was a useful adjunctive diagnostic tool in the diagnosis of thyroid nodules with suspicious ultrasound features regardless of size.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProper Indication of BRAFV600E Mutation Testing in Fine-Needle Aspirates of Thyroid Nodules-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJieun Koh-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJin Young Kwak-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorKyung Hwa Han-
dc.identifier.doi10.1371/journal.pone.0064505-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02595-
dc.contributor.localIdA04182-
dc.contributor.localIdA04267-
dc.relation.journalcodeJ02540-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.alternativeNameHan, Kyung Hwa-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.contributor.affiliatedAuthorHan, Kyung Hwa-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number5-
dc.citation.startPagee64505-
dc.identifier.bibliographicCitationPLoS One, Vol.8(5) : e64505, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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