Cited 42 times in
Alteration of Synaptic Activity–Regulating Genes Underlying Functional Improvement by Long-term Exposure to an Enriched Environment in the Adult Brain
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.contributor.author | 박은숙 | - |
dc.contributor.author | 서정화 | - |
dc.contributor.author | 유지혜 | - |
dc.contributor.author | 이민영 | - |
dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2014-12-18T08:41:16Z | - |
dc.date.available | 2014-12-18T08:41:16Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1545-9683 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86769 | - |
dc.description.abstract | Background. Housing animals in an enriched environment (EE) enhances behavioral function. However, the mechanism underlying this EE-mediated functional improvement and the resultant changes in gene expression have yet to be elucidated. Objectives. We attempted to investigate the underlying mechanisms associated with long-term exposure to an EE by evaluating gene expression patterns. Methods. We housed 6-week-old CD-1 (ICR) mice in standard cages or an EE comprising a running wheel, novel objects, and social interaction for 2 months. Motor and cognitive performances were evaluated using the rotarod test and passive avoidance test, and gene expression profile was investigated in the cerebral hemispheres using microarray and gene set enrichment analysis (GSEA). Results. In behavioral assessment, an EE significantly enhanced rotarod performance and short-term working memory. Microarray analysis revealed that genes associated with neuronal activity were significantly altered by an EE. GSEA showed that genes involved in synaptic transmission and postsynaptic signal transduction were globally upregulated, whereas those associated with reuptake by presynaptic neurotransmitter transporters were downregulated. In particular, both microarray and GSEA demonstrated that EE exposure increased opioid signaling, acetylcholine release cycle, and postsynaptic neurotransmitter receptors but decreased Na+/Cl−-dependent neurotransmitter transporters, including dopamine transporter Slc6a3 in the brain. Western blotting confirmed that SLC6A3, DARPP32 (PPP1R1B), and P2RY12 were largely altered in a region-specific manner. Conclusion. An EE enhanced motor and cognitive function through the alteration of synaptic activity–regulating genes, improving the efficient use of neurotransmitters and synaptic plasticity by the upregulation of genes associated with postsynaptic receptor activity and downregulation of presynaptic reuptake by neurotransmitter transporters. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NEUROREHABILITATION AND NEURAL REPAIR | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Avoidance Learning/physiology | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins/genetics | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins/metabolism | - |
dc.subject.MESH | Dopamine and cAMP-Regulated Phosphoprotein 32/genetics | - |
dc.subject.MESH | Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism | - |
dc.subject.MESH | Enkephalins/genetics | - |
dc.subject.MESH | Enkephalins/metabolism | - |
dc.subject.MESH | Environment* | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Gene Expression Regulation/physiology* | - |
dc.subject.MESH | Interpersonal Relations | - |
dc.subject.MESH | Memory, Short-Term/physiology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Motor Activity/physiology* | - |
dc.subject.MESH | Neuronal Plasticity/physiology* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Protein Precursors/genetics | - |
dc.subject.MESH | Protein Precursors/metabolism | - |
dc.subject.MESH | Receptors, Dopamine D1/genetics | - |
dc.subject.MESH | Receptors, Dopamine D1/metabolism | - |
dc.subject.MESH | Receptors, Purinergic P2Y12/genetics | - |
dc.subject.MESH | Receptors, Purinergic P2Y12/metabolism | - |
dc.title | Alteration of Synaptic Activity–Regulating Genes Underlying Functional Improvement by Long-term Exposure to an Enriched Environment in the Adult Brain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Min-Young Lee | - |
dc.contributor.googleauthor | Ji Hea Yu | - |
dc.contributor.googleauthor | Ji Yeon Kim | - |
dc.contributor.googleauthor | Jung Hwa Seo | - |
dc.contributor.googleauthor | Eun Sook Park | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Hyongbum Kim | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.identifier.doi | 10.1177/1545968313481277 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02784 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01611 | - |
dc.contributor.localId | A01906 | - |
dc.contributor.localId | A02521 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J02360 | - |
dc.identifier.eissn | 1552-6844 | - |
dc.identifier.pmid | 23558143 | - |
dc.identifier.url | http://nnr.sagepub.com/content/27/6/561.long | - |
dc.subject.keyword | enriched environment | - |
dc.subject.keyword | gene expression | - |
dc.subject.keyword | gene set enrichment analysis | - |
dc.subject.keyword | synaptic activity | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Park, Eun Sook | - |
dc.contributor.alternativeName | Seo, Jung Hwa | - |
dc.contributor.alternativeName | Yu, Ji Hea | - |
dc.contributor.alternativeName | Lee, Min Young | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | Lee, Min Young | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Park, Eun Sook | - |
dc.contributor.affiliatedAuthor | Seo, Jung Hwa | - |
dc.contributor.affiliatedAuthor | Yu, Ji Hea | - |
dc.contributor.affiliatedAuthor | Cho, Sung Rae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 27 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 561 | - |
dc.citation.endPage | 574 | - |
dc.identifier.bibliographicCitation | NEUROREHABILITATION AND NEURAL REPAIR, Vol.27(6) : 561-574, 2013 | - |
dc.identifier.rimsid | 29193 | - |
dc.type.rims | ART | - |
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