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The feasibility of 18F-fluorodeoxyglucose-positron emission tomography uptake as a prognostic factor for paranasal sinus malignancy

Authors
 Seol Jeong-Hun  ;  Kim Jinna  ;  Lee Jong-Doo  ;  Lee Jeung-Gweon  ;  Yoon Joo-Heon  ;  Kim Chang-Hoon 
Citation
 AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, Vol.27(2) : 118-122, 2013 
Journal Title
 AMERICAN JOURNAL OF RHINOLOGY & ALLERGY 
ISSN
 1945-8924 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/diagnostic imaging* ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Disease Progression ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18/pharmacokinetics* ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Nose Neoplasms/diagnostic imaging* ; Nose Neoplasms/mortality ; Nose Neoplasms/pathology ; Paranasal Sinuses/diagnostic imaging* ; Paranasal Sinuses/pathology ; Positron-Emission Tomography/methods* ; Prognosis ; Radiopharmaceuticals/pharmacokinetics* ; Retrospective Studies ; Survival Analysis
Keywords
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/diagnostic imaging* ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Disease Progression ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18/pharmacokinetics* ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Nose Neoplasms/diagnostic imaging* ; Nose Neoplasms/mortality ; Nose Neoplasms/pathology ; Paranasal Sinuses/diagnostic imaging* ; Paranasal Sinuses/pathology ; Positron-Emission Tomography/methods* ; Prognosis ; Radiopharmaceuticals/pharmacokinetics* ; Retrospective Studies ; Survival Analysis
Abstract
BACKGROUND: There is a correlation between (18)F-fluorodeoxyglucose (FDG) uptake and the level of intracellular metabolic tumor activity, which in turn may be associated with active proliferation, invasion, and prognosis as well as distant metastases in head and neck cancer. This study was designed to assess whether tumor uptake of FDG positron emission tomography (PET) expressed as the maximum standardized uptake value (SUVmax) can be used to predict survival in subjects with paranasal sinus malignancy. METHODS: We enrolled 42 consecutive subjects with a histological diagnosis of squamous cell carcinoma in paranasal sinus malignancy, into a retrospective institutional imaging trial. Thirty-eight subjects (90.5%) underwent a baseline FDG-PET scan before curative treatment and were eligible for analysis. RESULTS: A total of 38 subjects with paranasal sinus malignancy undergoing PET/computed tomography imaging in the initial stages were assessed separately for a potential correlation between SUVmax and T staging, histological grading, and overall survival. Log-rank testing revealed a significant correlation between overall survival and histological grading (p = 0.046); and there was some correlation between SUVmax and histological grading, but not significantly different. The receiver operation characteristic curve was identified for cutoff value of SUVmax as a prognostic factor. We compared the low tumor of the SUVmax group with the high tumor of the SUVmax group divided by the cutoff value of SUVmax. We did find a significant correlation between SUVmax and disease control and mortality (p = 0.003, p < 0.001). CONCLUSION: In our study, we concluded that subjects with higher tumor FDG uptakes should be considered for a more aggressive disease.
Full Text
http://www.ingentaconnect.com/content/ocean/ajra/2013/00000027/00000002/art00012?token=004d1685d3346b7b76504c4866462544496e2f783f34427c6a332b25757d5c4f6d4e227af2791
DOI
10.2500/ajra.2013.27.3848
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
Lee, Jong Doo(이종두)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86762
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