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Delivery of Cancer Therapeutics Using Nanotechnology

Authors
 Eun-Kyung Lim  ;  Eunji Jang  ;  Kwangyeol Lee  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 PHARMACEUTICS, Vol.5(2) : 294-317, 2013 
Journal Title
 PHARMACEUTICS 
Issue Date
2013
Keywords
nanoparticles ; nanotechnology ; drug delivery ; cancer ; theranostic nanoparticles
Abstract
Nanoparticles have been investigated as drug carriers, because they provide a great opportunity due to their advantageous features: (i) various formulations using organic/inorganic materials, (ii) easy modification of targeting molecules, drugs or other molecules on them, (iii) effective delivery to target sites, resulting in high therapeutic efficacy and (iv) controlling drug release by external/internal stimuli. Because of these features, therapeutic efficacy can be improved and unwanted side effects can be reduced. Theranostic nanoparticles have been developed by incorporating imaging agents in drug carriers as all-in-one system, which makes it possible to diagnose and treat cancer by monitoring drug delivery behavior simultaneously. Recently, stimuli-responsive, activatable nanomaterials are being applied that are capable of producing chemical or physical changes by external stimuli. By using these nanoparticles, multiple tasks can be carried out simultaneously, e.g., early and accurate diagnosis, efficient cataloguing of patient groups of personalized therapy and real-time monitoring of disease progress. In this paper, we describe various types of nanoparticles for drug delivery systems, as well as theranostic systems.
Files in This Item:
T201301230.pdf Download
DOI
10.3390/pharmaceutics5020294
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
Yonsei Authors
Lim, Eun Kyung(임은경)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86735
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