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Delivery of Cancer Therapeutics Using Nanotechnology

Authors
 Eun-Kyung Lim  ;  Eunji Jang  ;  Kwangyeol Lee  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 Pharmaceutics, Vol.5(2) : 294-317, 2013 
Journal Title
 Pharmaceutics 
ISSN
 1999-4923 
Issue Date
2013
Abstract
Nanoparticles have been investigated as drug carriers, because they provide a great opportunity due to their advantageous features: (i) various formulations using organic/inorganic materials, (ii) easy modification of targeting molecules, drugs or other molecules on them, (iii) effective delivery to target sites, resulting in high therapeutic efficacy and (iv) controlling drug release by external/internal stimuli. Because of these features, therapeutic efficacy can be improved and unwanted side effects can be reduced. Theranostic nanoparticles have been developed by incorporating imaging agents in drug carriers as all-in-one system, which makes it possible to diagnose and treat cancer by monitoring drug delivery behavior simultaneously. Recently, stimuli-responsive, activatable nanomaterials are being applied that are capable of producing chemical or physical changes by external stimuli. By using these nanoparticles, multiple tasks can be carried out simultaneously, e.g., early and accurate diagnosis, efficient cataloguing of patient groups of personalized therapy and real-time monitoring of disease progress. In this paper, we describe various types of nanoparticles for drug delivery systems, as well as theranostic systems.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86735
DOI
10.3390/pharmaceutics5020294
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소)
Yonsei Authors
임은경(Lim, Eun Kyung) ; 허용민(Huh, Yong Min)
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