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The effect of orally administered epigallocatechin-3-gallate on ligature-induced periodontitis in rats

Authors
 A.-R. Cho  ;  J.-H. Kim  ;  D.-E. Lee  ;  J.-S. Lee  ;  U.-W. Jung  ;  E.-J. Bak  ;  Y.-J. Yoo  ;  W.-G. Chung  ;  S.-H. Choi 
Citation
 Journal of Periodontal Research, Vol.48(2) : 1-9, 2013 
Journal Title
 Journal of Periodontal Research 
ISSN
 0022-3484 
Issue Date
2013
Abstract
BACKGROUND AND OBJECTIVE: Epigallocatechin-3-gallate (EGCG) is known for its beneficial properties, including anti-inflammatory and anti-oxidative activities. Recently, reports have suggested that EGCG plays a pivotal role in regulating cytokine expression and osteoclastic activity. In the present study, we investigated whether orally administered EGCG has a therapeutic effect on ligature-induced periodontitis. MATERIALS AND METHODS: Forty-eight Sprague-Dawley rats were treated with EGCG or phosphate-buffered saline. Periodontitis was induced by tying a ligature for 7 d. After removing ligation, EGCG (200 mg/kg) or phosphate-buffered saline was administered via oral gavage on a daily basis. Rats were killed after 1, 2 and 4 wk of administration. Histologic and histomorphometric analyses, tartrate resistant acid phosphatase staining and immunohistochemistry were carried out. RESULTS: In the control group, bone loss did not recover even after the causative factor of periodontitis was eliminated. On the other hand, distance from cemento-enamel junction to alveolar bone crest, long junctional epithelium and collagen destruction were reduced in the EGCG group. Decreased interleukin (IL)-6 expression was shown from the early stage of EGCG administration, followed by reduced tumor necrosis factor (TNF) expression at week 4 EGCG group. The CT area showed a higher decrease of IL-6 expression between the control and EGCG group than alveolar bone area. Downregulation of TNF and IL-6 expression led to a decrease in osteoclast number and activity, which resulted in reduced bone loss. CONCLUSIONS: Systemic administration of EGCG could have a therapeutic effect on damaged periodontal tissue. Inhibited cytokine expression, including TNF and IL-6 is responsible for the reduction in osteoclast formation, osteoclastic activity and collagen destruction.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86657
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jre.12071/abstract
DOI
10.1111/jre.12071
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Periodontal Tissue Regeneration (치주조직재생연구소)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
김지혜(Kim, Ji Hye)
박은정(Bak, Eun-Jung)
유윤정(Yoo, Yun Jung)
이동은(Lee, Dong Eun)
이중석(Lee, Jung Seok)
정의원(Jung, Ui Won)
조아란(Cho, Ah Ran)
최성호(Choi, Seong Ho)
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