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Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague–Dawley rats fed on a high fat diet

Authors
 Yoonsu Cho  ;  Ji Hyung Chung  ;  Hyun Ju Do  ;  Hyun Ju Jeon  ;  Taewon Jin  ;  Min-Jeong Shin 
Citation
 Food Chemistry, Vol.139(1-4) : 720-727, 2013 
Journal Title
 Food Chemistry 
ISSN
 0308-8146 
Issue Date
2013
Abstract
The modulatory effects of daily fisetin supplementation for 8 weeks on genes involved in hepatic lipogenesis and gluconeogenesis and hyperglycemia in rats fed a high fat (HF) diet were evaluated. Elevated levels of triglyceride (TG), along with hepatic TG content and glucose concentrations in a high fat diet group were found to be reduced by fisetin supplementation. The high fat diet significantly increased hepatic mRNA expressions of PPARγ, SREBP1C and SCD-1 genes in comparison to the control diet, which was subsequently reversed by supplementation with fisetin. In addition, fisetin supplementation significantly reduced hepatic mRNA abundance of FAS, ATPCL and G6Pase compared to the control group. Finally, epididymal mRNA abundance of GLUT4 was significantly increased by fisetin supplementation, compared to levels in the control and HF groups. Enhancement of GLUT4 expression by fisetin was further confirmed in differentiated 3T3-L1 adipocytes. Fisetin supplementation decreases cardiovascular risks by ameliorating hepatic steatosis and lowering circulating glucose concentrations.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86629
Full Text
http://www.sciencedirect.com/science/article/pii/S0308814613000848
DOI
10.1016/j.foodchem.2013.01.060
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터)
Yonsei Authors
전현주(Jeon, Hyun Ju)
정지형(Chung, Ji Hyung)
진태원(Jin, Tae Won)
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