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Shear-wave elastography of invasive breast cancer: correlation between quantitative mean elasticity value and immunohistochemical profile

Authors
 Ji Hyun Youk  ;  Hye Mi Gweon  ;  Eun Ju Son  ;  Jeong-Ah Kim  ;  Joon Jeong 
Citation
 Breast Cancer Research and Treatment, Vol.138(1) : 119-126, 2013 
Journal Title
 Breast Cancer Research and Treatment 
ISSN
 0167-6806 
Issue Date
2013
Abstract
To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86474
Full Text
http://link.springer.com/article/10.1007%2Fs10549-013-2407-3
DOI
10.1007/s10549-013-2407-3
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
권혜미(Gweon, Hye Mi)
김정아(Kim, Jeong Ah)
손은주(Son, Eun Ju)
육지현(Youk, Ji Hyun) ORCID logo https://orcid.org/0000-0002-7787-780X
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