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Thy-1 knockdown retards wound repair in mouse skin

Authors
 Min-Jung Lee  ;  Jeong-Oh Shin  ;  Han-Sung Jung 
Citation
 Journal of Dermatological Science, Vol.69(2) : 95-104, 2013 
Journal Title
 Journal of Dermatological Science 
ISSN
 0923-1811 
Issue Date
2013
Abstract
BACKGROUND: Thy-1 (CD90) is a glycophosphatidyl-inositol (GPI) linked, cell surface glycoprotein located in non-caveolar lipid raft microdomains. OBJECTIVE: The biological functions of Thy-1 in many tissues are well known, however, its role in skin wound healing remains unclear. METHODS AND RESULTS: In fibroblasts cells, Thy-1 affects cell migration into the wound, cell proliferation and the cytoskeleton structure. Additionally, Thy-1 is mainly expressed in the wound dermis. Here, we compared the in vivo aspects of the repair process with and without Thy-1 siRNA treatment. Temporally blocking Thy-1 in skin wound regions worsens the quality of healing and retards the rate of wound healing. Specifically, the level of TGF-β1 at the wound continuously increased. CONCLUSION: These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86283
Full Text
http://www.sciencedirect.com/science/article/pii/S0923181112003544
DOI
10.1016/j.jdermsci.2012.11.009
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
신정오(Shin, Jeong Oh)
이민정(Lee, Min Jung)
정한성(Jung, Han Sung)
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