Cited 21 times in

Thy-1 knockdown retards wound repair in mouse skin

Authors
 Min-Jung Lee  ;  Jeong-Oh Shin  ;  Han-Sung Jung 
Citation
 JOURNAL OF DERMATOLOGICAL SCIENCE, Vol.69(2) : 95-104, 2013 
Journal Title
JOURNAL OF DERMATOLOGICAL SCIENCE
ISSN
 0923-1811 
Issue Date
2013
Keywords
Thy-1 ; Skin ; Wound ; TGF-β1 ; siRNA
Abstract
BACKGROUND:
Thy-1 (CD90) is a glycophosphatidyl-inositol (GPI) linked, cell surface glycoprotein located in non-caveolar lipid raft microdomains.
OBJECTIVE:
The biological functions of Thy-1 in many tissues are well known, however, its role in skin wound healing remains unclear.
METHODS AND RESULTS:
In fibroblasts cells, Thy-1 affects cell migration into the wound, cell proliferation and the cytoskeleton structure. Additionally, Thy-1 is mainly expressed in the wound dermis. Here, we compared the in vivo aspects of the repair process with and without Thy-1 siRNA treatment. Temporally blocking Thy-1 in skin wound regions worsens the quality of healing and retards the rate of wound healing. Specifically, the level of TGF-β1 at the wound continuously increased.
CONCLUSION:
These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process.
Full Text
http://www.sciencedirect.com/science/article/pii/S0923181112003544
DOI
10.1016/j.jdermsci.2012.11.009
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jeong Oh(신정오) ORCID logo https://orcid.org/0000-0002-6935-0936
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86283
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links