Cited 19 times in
Thy-1 knockdown retards wound repair in mouse skin
DC Field | Value | Language |
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dc.contributor.author | 신정오 | - |
dc.contributor.author | 이민정 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2014-12-18T08:25:35Z | - |
dc.date.available | 2014-12-18T08:25:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86283 | - |
dc.description.abstract | BACKGROUND: Thy-1 (CD90) is a glycophosphatidyl-inositol (GPI) linked, cell surface glycoprotein located in non-caveolar lipid raft microdomains. OBJECTIVE: The biological functions of Thy-1 in many tissues are well known, however, its role in skin wound healing remains unclear. METHODS AND RESULTS: In fibroblasts cells, Thy-1 affects cell migration into the wound, cell proliferation and the cytoskeleton structure. Additionally, Thy-1 is mainly expressed in the wound dermis. Here, we compared the in vivo aspects of the repair process with and without Thy-1 siRNA treatment. Temporally blocking Thy-1 in skin wound regions worsens the quality of healing and retards the rate of wound healing. Specifically, the level of TGF-β1 at the wound continuously increased. CONCLUSION: These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Thy-1 knockdown retards wound repair in mouse skin | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Min-Jung Lee | - |
dc.contributor.googleauthor | Jeong-Oh Shin | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1016/j.jdermsci.2012.11.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A02147 | - |
dc.contributor.localId | A02785 | - |
dc.relation.journalcode | J01370 | - |
dc.identifier.eissn | 1873-569X | - |
dc.identifier.pmid | Thy-1 ; Skin ; Wound ; TGF-β1 ; siRNA | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0923181112003544 | - |
dc.subject.keyword | Thy-1 | - |
dc.subject.keyword | Skin | - |
dc.subject.keyword | Wound | - |
dc.subject.keyword | TGF-β1 | - |
dc.subject.keyword | siRNA | - |
dc.contributor.alternativeName | Shin, Jeong Oh | - |
dc.contributor.alternativeName | Lee, Min Jung | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Shin, Jeong Oh | - |
dc.contributor.affiliatedAuthor | Lee, Min Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 69 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 104 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGICAL SCIENCE, Vol.69(2) : 95-104, 2013 | - |
dc.identifier.rimsid | 28890 | - |
dc.type.rims | ART | - |
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