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Cited 11 times in

Thy-1 knockdown retards wound repair in mouse skin

DC FieldValueLanguage
dc.contributor.author신정오-
dc.contributor.author이민정-
dc.contributor.author정한성-
dc.date.accessioned2014-12-18T08:25:35Z-
dc.date.available2014-12-18T08:25:35Z-
dc.date.issued2013-
dc.identifier.issn0923-1811-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86283-
dc.description.abstractBACKGROUND: Thy-1 (CD90) is a glycophosphatidyl-inositol (GPI) linked, cell surface glycoprotein located in non-caveolar lipid raft microdomains. OBJECTIVE: The biological functions of Thy-1 in many tissues are well known, however, its role in skin wound healing remains unclear. METHODS AND RESULTS: In fibroblasts cells, Thy-1 affects cell migration into the wound, cell proliferation and the cytoskeleton structure. Additionally, Thy-1 is mainly expressed in the wound dermis. Here, we compared the in vivo aspects of the repair process with and without Thy-1 siRNA treatment. Temporally blocking Thy-1 in skin wound regions worsens the quality of healing and retards the rate of wound healing. Specifically, the level of TGF-β1 at the wound continuously increased. CONCLUSION: These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJournal of Dermatological Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThy-1 knockdown retards wound repair in mouse skin-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorJeong-Oh Shin-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1016/j.jdermsci.2012.11.009-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03758-
dc.contributor.localIdA02147-
dc.contributor.localIdA02785-
dc.relation.journalcodeJ01370-
dc.identifier.pmidThy-1 ; Skin ; Wound ; TGF-β1 ; siRNA-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0923181112003544-
dc.subject.keywordThy-1-
dc.subject.keywordSkin-
dc.subject.keywordWound-
dc.subject.keywordTGF-β1-
dc.subject.keywordsiRNA-
dc.contributor.alternativeNameShin, Jeong Oh-
dc.contributor.alternativeNameLee, Min Jung-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorShin, Jeong Oh-
dc.contributor.affiliatedAuthorLee, Min Jung-
dc.rights.accessRightsnot free-
dc.citation.volume69-
dc.citation.number2-
dc.citation.startPage95-
dc.citation.endPage104-
dc.identifier.bibliographicCitationJournal of Dermatological Science, Vol.69(2) : 95-104, 2013-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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