AimsThe aim of this study is to identify the factors associated with nurses' perceptions and behaviours related to climate change and health (PBCH) according to their PBCH levels.DesignA cross-sectional study was used.MethodsThis study included a sample of 499 Korean nurses and adhered to the STROBE checklist. Data were collected from March 23 to May 10, 2023. Quantile regression analysis was performed, and PBCH levels were measured using the Korean version of the Climate Health and Nursing Tool.ResultsAcross all quantile groups, the experience of extreme weather events and awareness of climate change-coping facilitators were associated with PBCH. Differences were observed in factors associated with PBCH levels. Significant associations with PBCH were observed within the 75th percentile group, for having a religion, household income, and workplace climate friendliness. In the 25th percentile group, having a child, the number of sources for climate change-health-related information, and experience in setting climate change-health goals and strategies significantly influenced PBCH.ConclusionWe propose a differentiated strategy by elucidating the factors associated with high and low quantiles of PBCH levels.ImplicationsBy verifying specific factors associated with PBCH levels, nurses can enhance their preparedness to respond to the health risks posed by climate change in their clients.ImpactIdentifying common factors associated with all quantiles of nurses is important for establishing universal PBCH characteristics. Recognising the distinctions between high and low PBCH levels can aid in developing tailored nursing strategies to enhance PBCH among nurses.Reporting MethodThis study adhered to the STROBE guidelines.Patient or Public ContributionNo Patient or Public Contribution.