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Brain Perfusion, Atrophy, and Dopaminergic Changes in Amyloid Negative Logopenic Primary Progressive Aphasia

Authors
 Sungwoo Kang  ;  Seun Jeon  ;  Young-Gun Lee  ;  Mijin Yun  ;  HyangHee Kim  ;  Byoung Seok Ye 
Citation
 SCIENTIFIC REPORTS, Vol.15(1) : 8429, 2025-03 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2025-03
MeSH
Aged ; Amyloid beta-Peptides / metabolism ; Aphasia, Primary Progressive* / diagnostic imaging ; Aphasia, Primary Progressive* / metabolism ; Aphasia, Primary Progressive* / pathology ; Aphasia, Primary Progressive* / physiopathology ; Atrophy ; Brain* / diagnostic imaging ; Brain* / metabolism ; Brain* / pathology ; Case-Control Studies ; Dopamine Plasma Membrane Transport Proteins / metabolism ; Dopamine* / metabolism ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron-Emission Tomography
Keywords
Alzheimer’s disease ; Lewy body disease ; Logopenic primary progressive aphasia ; Positron emission tomography
Abstract
Although most cases of logopenic variant primary progressive aphasia (lvPPA) are caused by Alzheimer's disease (AD), Lewy body disease (LBD) has also been reported. We assessed brain perfusion, atrophy, dopamine transporter (DAT) uptake, and language function among patients with lvPPA based on beta-amyloid. Thirty-three patients with lvPPA and 28 healthy controls (HCs) underwent MRI, 18F-florbetaben PET, and early- and late-phase DAT PET. All patients completed a language test. General linear models were applied to investigate the association of brain imaging with the aphasia quotient (AQ) and repetition scores. 20 (60.6%) and 13 (39.4%) of the lvPPA patients were amyloid-positive (lvPPAA+) and -negative (lvPPAA-), respectively. Language function was comparable between groups. Compared to HCs, the lvPPAA+ had lower perfusion across widespread brain regions, the lvPPAA- had lower perfusion in the left supramarginal and angular gyri, and both groups had lower DAT in the left caudate and bilateral substantia nigra. In the lvPPAA-, AQ and repetition scores were positively correlated with perfusion in the left temporal and inferior parietal cortices, with perfusion in the left supramarginal gyrus mediating the effect of left substantia nigra DAT. Although AD is the most common underlying pathology of lvPPA, LBD may contribute to the logopenic phenotype.
Files in This Item:
T202502947.pdf Download
DOI
10.1038/s41598-025-90116-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Kang, Sung Woo(강성우)
Kim, Hyang Hee(김향희) ORCID logo https://orcid.org/0000-0003-4949-2512
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yun, Mijin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Jeon, Seun(전세운) ORCID logo https://orcid.org/0000-0003-2817-3352
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/205982
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