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Predictors associated with the rate of progression of nigrostriatal degeneration in Parkinson's disease

Authors
 Han Soo Yoo  ;  Han-Kyeol Kim  ;  Hye Sun Lee  ;  So Hoon Yoon  ;  Han Kyu Na  ;  Sung Woo Kang  ;  Jae-Hoon Lee  ;  Young Hoon Ryu  ;  Chul Hyoung Lyoo 
Citation
 JOURNAL OF NEUROLOGY, Vol.271(8) : 5213-5222, 2024-08 
Journal Title
JOURNAL OF NEUROLOGY
ISSN
 0340-5354 
Issue Date
2024-08
MeSH
Aged ; Corpus Striatum* / diagnostic imaging ; Corpus Striatum* / metabolism ; Corpus Striatum* / pathology ; Disease Progression* ; Dopamine Plasma Membrane Transport Proteins* / metabolism ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging ; Parkinson Disease* / metabolism ; Parkinson Disease* / pathology ; Positron-Emission Tomography* ; Retrospective Studies ; Substantia Nigra / diagnostic imaging ; Substantia Nigra / metabolism ; Substantia Nigra / pathology ; Tropanes
Keywords
Caudate ; Dopamine transporter ; Nigrostriatal degeneration ; Parkinson’s disease ; Progression ; Putamen
Abstract
BackgroundParkinson's disease (PD) manifests as a wide variety of clinical phenotypes and its progression varies greatly. However, the factors associated with different disease progression remain largely unknown.MethodsIn this retrospective cohort study, we enrolled 113 patients who underwent 18F-FP-CIT PET scan twice. Given the negative exponential progression pattern of dopamine loss in PD, we applied the natural logarithm to the specific binding ratio (SBR) of two consecutive 18F-FP-CIT PET scans and conducted linear mixed model to calculate individual slope to define the progression rate of nigrostriatal degeneration. We investigated the clinical and dopamine transporter (DAT) availability patterns associated with the progression rate of dopamine depletion in each striatal sub-region.ResultsMore symmetric parkinsonism, the presence of dyslipidemia, lower K-MMSE total score, and lower anteroposterior gradient of the mean putaminal SBR were associated with faster progression rate of dopamine depletion in the caudate nucleus. More symmetric parkinsonism and lower anteroposterior gradient of the mean putaminal SBR were associated with faster depletion of dopamine in the anterior putamen. Older age at onset, more symmetric parkinsonism, the presence of dyslipidemia, and lower anteroposterior gradient of the mean putaminal SBR were associated with faster progression rate of dopamine depletion in the posterior putamen. Lower striatal mean SBR predicted the development of LID, while lower mean SBR in the caudate nuclei predicted the development of dementia.DiscussionOur results suggest that the evaluation of baseline clinical features and patterns of DAT availability can predict the progression of PD and its prognosis.
Full Text
https://link.springer.com/article/10.1007/s00415-024-12477-z
DOI
10.1007/s00415-024-12477-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Sung Woo(강성우)
Kim, Han kyeol(김한결) ORCID logo https://orcid.org/0000-0002-7650-6708
Na, Han Kyu(나한규)
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200897
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